Transfusions decrease CBF and OEF without altering CMRO2
| . | Median (25th-75th IQR) . | P . | ||
|---|---|---|---|---|
| Pretransfusion . | Posttransfusion . | Δ . | ||
| CBF, mL/100 g per min | ||||
| Whole brain | 88.0 (73.4-110.8) | 82.4 (70.9-99.6) | −6.5 (1.2 to −18.7) | .005* |
| Gray matter | 108.7 (90.5-129.4) | 99.5 (84.4-122.4) | −11.9 (−4.3 to −23.6) | .01* |
| White matter | 59.5 (48.0-72.5) | 55.7 (48.8-60.7) | −2.5 (0.3 to −11.5) | .03* |
| OEF, % | ||||
| Whole brain | 34.4 (32.1-38.5) | 31.2 (29.6-33.8) | −2.0 (−1.0 to −5.1) | <.0001* |
| Gray matter | 35.1 (32.9-37.4) | 32.5 (30.6-33.9) | −2.3 (−0.4 to −4.5) | <.0001* |
| White matter | 33.5 (31.1-38.9) | 30.6 (28.8-33.8) | −2.5 (−0.9 to −5.8) | <.0001* |
| CMRO2, mL/100 g per min | ||||
| Whole brain | 3.2 (2.7-3.6) | 3.2 (2.5-3.7) | −0.1 (0.1 to −0.8) | .07 |
| Gray matter | 4.0 (3.3-4.3) | 4.0 (3.1-4.4) | −0.1 (0.0 to −0.6) | .08 |
| White matter | 2.4 (1.9-3.0) | 2.3 (1.9-2.5) | −0.1 (0.1 to −0.5) | .10 |
| . | Median (25th-75th IQR) . | P . | ||
|---|---|---|---|---|
| Pretransfusion . | Posttransfusion . | Δ . | ||
| CBF, mL/100 g per min | ||||
| Whole brain | 88.0 (73.4-110.8) | 82.4 (70.9-99.6) | −6.5 (1.2 to −18.7) | .005* |
| Gray matter | 108.7 (90.5-129.4) | 99.5 (84.4-122.4) | −11.9 (−4.3 to −23.6) | .01* |
| White matter | 59.5 (48.0-72.5) | 55.7 (48.8-60.7) | −2.5 (0.3 to −11.5) | .03* |
| OEF, % | ||||
| Whole brain | 34.4 (32.1-38.5) | 31.2 (29.6-33.8) | −2.0 (−1.0 to −5.1) | <.0001* |
| Gray matter | 35.1 (32.9-37.4) | 32.5 (30.6-33.9) | −2.3 (−0.4 to −4.5) | <.0001* |
| White matter | 33.5 (31.1-38.9) | 30.6 (28.8-33.8) | −2.5 (−0.9 to −5.8) | <.0001* |
| CMRO2, mL/100 g per min | ||||
| Whole brain | 3.2 (2.7-3.6) | 3.2 (2.5-3.7) | −0.1 (0.1 to −0.8) | .07 |
| Gray matter | 4.0 (3.3-4.3) | 4.0 (3.1-4.4) | −0.1 (0.0 to −0.6) | .08 |
| White matter | 2.4 (1.9-3.0) | 2.3 (1.9-2.5) | −0.1 (0.1 to −0.5) | .10 |
Wilcoxon signed-rank test was used for all comparisons. Bold P values indicate statistical significance.
P values remaining significant after Benjamani-Hochberg procedure for multiple-comparison adjustment.