Response to treatment as assessed by IMWG criteria
| . | ITT population . | High-risk cytogenetics . | Standard-risk cytogenetics . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Response . | Rd continuous (n = 535) . | Rd18 (n = 541) . | MPT (n = 547) . | Rd continuous (n = 43) . | Rd18 (n = 52) . | MPT (n = 47) . | Rd continuous (n = 205) . | Rd18 (n = 209) . | MPT (n = 206) . |
| ORR, n (%) | 432 (81) | 425 (79) | 369 (67) | 33 (77) | 35 (67) | 32 (68) | 166 (81) | 167 (80) | 146 (71) |
| CR | 119 (22) | 110 (20) | 68 (12) | 5 (12) | 7 (13) | 0 | 43 (21) | 45 (22) | 35 (17) |
| VGPR | 141 (26) | 145 (27) | 99 (18) | 8 (19) | 11 (21) | 5 (11) | 58 (28) | 54 (26) | 45 (22) |
| PR | 172 (32) | 170 (31) | 202 (37) | 20 (47) | 17 (33) | 27 (57) | 65 (32) | 68 (33) | 66 (32) |
| SD, n (%) | 66 (12) | 83 (15) | 116 (21) | 6 (14) | 12 (23) | 11 (23) | 26 (13) | 29 (14) | 37 (18) |
| PD, n (%) | 10 (2) | 6 (1) | 17 (3) | 1 (2) | 0 | 2 (4) | 4 (2) | 4 (2) | 5 (2) |
| NE, n (%) | 27 (5) | 27 (5) | 45 (8) | 3 (7) | 5 (10) | 2 (4) | 9 (4) | 9 (4) | 18 (9) |
| Odds ratio, Rd continuous vs MPT | 2.02 | 1.55 | 1.75 | ||||||
| 95% CI | 1.53-2.68 | 0.61-3.95 | 1.10-2.77 | ||||||
| . | ITT population . | High-risk cytogenetics . | Standard-risk cytogenetics . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Response . | Rd continuous (n = 535) . | Rd18 (n = 541) . | MPT (n = 547) . | Rd continuous (n = 43) . | Rd18 (n = 52) . | MPT (n = 47) . | Rd continuous (n = 205) . | Rd18 (n = 209) . | MPT (n = 206) . |
| ORR, n (%) | 432 (81) | 425 (79) | 369 (67) | 33 (77) | 35 (67) | 32 (68) | 166 (81) | 167 (80) | 146 (71) |
| CR | 119 (22) | 110 (20) | 68 (12) | 5 (12) | 7 (13) | 0 | 43 (21) | 45 (22) | 35 (17) |
| VGPR | 141 (26) | 145 (27) | 99 (18) | 8 (19) | 11 (21) | 5 (11) | 58 (28) | 54 (26) | 45 (22) |
| PR | 172 (32) | 170 (31) | 202 (37) | 20 (47) | 17 (33) | 27 (57) | 65 (32) | 68 (33) | 66 (32) |
| SD, n (%) | 66 (12) | 83 (15) | 116 (21) | 6 (14) | 12 (23) | 11 (23) | 26 (13) | 29 (14) | 37 (18) |
| PD, n (%) | 10 (2) | 6 (1) | 17 (3) | 1 (2) | 0 | 2 (4) | 4 (2) | 4 (2) | 5 (2) |
| NE, n (%) | 27 (5) | 27 (5) | 45 (8) | 3 (7) | 5 (10) | 2 (4) | 9 (4) | 9 (4) | 18 (9) |
| Odds ratio, Rd continuous vs MPT | 2.02 | 1.55 | 1.75 | ||||||
| 95% CI | 1.53-2.68 | 0.61-3.95 | 1.10-2.77 | ||||||
IMWG, International Myeloma Working Group; NE, not evaluable; PD, progressive disease; SD, stable disease.