| Double-hit | High-grade lymphoma with rearrangements of myc and bcl-2 or myc and bcl-6; must be diagnosed with FISH or more advanced genomic techniques. |
| Triple-hit | High-grade lymphoma with rearrangements of myc and bcl-2 and bcl-6; must be diagnosed with FISH or more advanced genomic techniques. |
| Double-expressor | Protein expression of MYC and BCL-2 and/or BCL-6; measured by using an immunohistochemistry cutoff for the percentage of positive cells. |
| Double-hit | High-grade lymphoma with rearrangements of myc and bcl-2 or myc and bcl-6; must be diagnosed with FISH or more advanced genomic techniques. |
| Triple-hit | High-grade lymphoma with rearrangements of myc and bcl-2 and bcl-6; must be diagnosed with FISH or more advanced genomic techniques. |
| Double-expressor | Protein expression of MYC and BCL-2 and/or BCL-6; measured by using an immunohistochemistry cutoff for the percentage of positive cells. |