Table 5.

Associations between SCD-related vascular complications and the indirect hemolysis index (quartile 1 to 3 vs quartile 4 of the hemolysis index): multivariate analysis in adult and pediatric SS or Sβ0 populations

% of patients with the complication depending on hemolysis indexMultivariate analysis*
Complication, N (%)N event/N totalQuartiles 1 to 3Quartile 4OR95% CIP*P†
Adult SS or Sβ0phenotype population (≥18 y old, n = 710)        
 TRV >2.5 m/s‡ 69/223 27.4 45.2 2.17 0.92-5.14 .078 .374 
 TRV >3 m/s‡ 6/223 2.4 3.7 2.17 0.92-5.14 .078 .374 
 Urine ACR >30 mg/g§ 249/557 41.2 60.5 1.80 1.10-2.95 .019 .425 
 Leg ulcer, lifetime 128/710 15.5 28.2 2.11 1.22-3.62 .007 .059 
 Priapism, lifetime‖ 81/306 24.6 32.9 1.62 0.80-3.29 .181 .719 
 Stroke, lifetime 13/710 1.36 3.83 2.86 0.78-10.5 .112 .329 
 Osteonecrosis, lifetime 136/710 18.3 22.5 1.30 0.76-2.25 .337 .307 
Pediatric SS or Sβ0phenotype population (<18 y old, n = 1041)        
 TRV >2.5 m/s‡ 26/112 19.7 29.4 1.69 0.62-4.58 .299 .158 
 TRV >3 m/s‡ 2/112 0.2 4.6 1.69 0.62-4.58 .299 .158 
 Urine ACR >30 mg/g§ 324/794 34.5 54.5 1.49 1.00-2.21 .046 .156 
 Leg ulcer, lifetime 38/1041 2.6 6.1 2.19 0.97-4.93 .058 .041 
 Priapism, lifetime‖ 45/503 7.6 11.7 1.17 0.57-2.41 .665 .751 
 Stroke, lifetime 10/1041 1.0 0.8 NA NA NA NA 
 Osteonecrosis, lifetime 73/1041 5.3 11.0 1.30 0.73-2.33 .367 .368 
% of patients with the complication depending on hemolysis indexMultivariate analysis*
Complication, N (%)N event/N totalQuartiles 1 to 3Quartile 4OR95% CIP*P†
Adult SS or Sβ0phenotype population (≥18 y old, n = 710)        
 TRV >2.5 m/s‡ 69/223 27.4 45.2 2.17 0.92-5.14 .078 .374 
 TRV >3 m/s‡ 6/223 2.4 3.7 2.17 0.92-5.14 .078 .374 
 Urine ACR >30 mg/g§ 249/557 41.2 60.5 1.80 1.10-2.95 .019 .425 
 Leg ulcer, lifetime 128/710 15.5 28.2 2.11 1.22-3.62 .007 .059 
 Priapism, lifetime‖ 81/306 24.6 32.9 1.62 0.80-3.29 .181 .719 
 Stroke, lifetime 13/710 1.36 3.83 2.86 0.78-10.5 .112 .329 
 Osteonecrosis, lifetime 136/710 18.3 22.5 1.30 0.76-2.25 .337 .307 
Pediatric SS or Sβ0phenotype population (<18 y old, n = 1041)        
 TRV >2.5 m/s‡ 26/112 19.7 29.4 1.69 0.62-4.58 .299 .158 
 TRV >3 m/s‡ 2/112 0.2 4.6 1.69 0.62-4.58 .299 .158 
 Urine ACR >30 mg/g§ 324/794 34.5 54.5 1.49 1.00-2.21 .046 .156 
 Leg ulcer, lifetime 38/1041 2.6 6.1 2.19 0.97-4.93 .058 .041 
 Priapism, lifetime‖ 45/503 7.6 11.7 1.17 0.57-2.41 .665 .751 
 Stroke, lifetime 10/1041 1.0 0.8 NA NA NA NA 
 Osteonecrosis, lifetime 73/1041 5.3 11.0 1.30 0.73-2.33 .367 .368 
*

Adjustment for sex, country, and SCD phenotype.

†

Plus adjustment for Hb.

‡

Percentages calculated for patients from Mali and Cameroon only.

§

Additional adjustment for the laboratory technique used.

‖

Percentages calculated for males only.

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