Associations between SCD-related vascular complications and hemoglobin (quartile 1 vs quartiles 2 to 4 of hemoglobin): multivariate analysis in adult and pediatric SS or Sβ0 populations
| . | . | % of patients with the complication depending on Hb level . | Multivariate analysis* . | |||
|---|---|---|---|---|---|---|
| Complication, N (%) . | N event/N total . | Quartile 1 . | Quartiles 2 to 4 . | OR . | 95% CI . | P* . |
| Adult SS or Sβ0phenotype population (≥18 y old, n = 710) | ||||||
| TRV >2.5 m/s† | 69/223 | 55.3 | 27.2 | 3.22 | 1.48-7.00 | .003 |
| TRV >3m/s | 6/223 | 10.5 | 1.2 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 249/557 | 59.8 | 41.0 | 2.05 | 1.27-3.31 | .003 |
| Leg ulcer, lifetime | 128/710 | 25.2 | 16.8 | 1.76 | 1.11-2.79 | .017 |
| Priapism, lifetime§ | 81/306 | 33.3 | 24.0 | 1.66 | 0.84-3.27 | .144 |
| Stroke, lifetime | 13/710 | 2.3 | 1.8 | 1.27 | 0.34-4.70 | .721 |
| Osteonecrosis, lifetime | 136/710 | 18.3 | 18.8 | 0.99 | 0.60-1.62 | .957 |
| Pediatric SS or Sβ0phenotype population (<18 y old, n = 1041) | ||||||
| TRV >2.5 m/s† | 26/112 | 27.8 | 19.1 | 1.67 | 0.63-4.43 | .297 |
| TRV >3 m/s† | 2/112 | 2.8 | 1.5 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 324/794 | 49.8 | 37.3 | 1.47 | 1.05-2.06 | .003 |
| Leg ulcer, lifetime | 38/1041 | 4.2 | 3.5 | 1.28 | 0.63-2.62 | .493 |
| Priapism, lifetime§ | 45/503 | 9.1 | 9.0 | 0.84 | 0.43-1.67 | .625 |
| Stroke, lifetime | 10/1041 | 0.7 | 1.1 | 0.49 | 0.10-2.42 | .381 |
| Osteonecrosis, lifetime | 73/1041 | 9.4 | 6.1 | 1.25 | 0.73-2.15 | .408 |
| . | . | % of patients with the complication depending on Hb level . | Multivariate analysis* . | |||
|---|---|---|---|---|---|---|
| Complication, N (%) . | N event/N total . | Quartile 1 . | Quartiles 2 to 4 . | OR . | 95% CI . | P* . |
| Adult SS or Sβ0phenotype population (≥18 y old, n = 710) | ||||||
| TRV >2.5 m/s† | 69/223 | 55.3 | 27.2 | 3.22 | 1.48-7.00 | .003 |
| TRV >3m/s | 6/223 | 10.5 | 1.2 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 249/557 | 59.8 | 41.0 | 2.05 | 1.27-3.31 | .003 |
| Leg ulcer, lifetime | 128/710 | 25.2 | 16.8 | 1.76 | 1.11-2.79 | .017 |
| Priapism, lifetime§ | 81/306 | 33.3 | 24.0 | 1.66 | 0.84-3.27 | .144 |
| Stroke, lifetime | 13/710 | 2.3 | 1.8 | 1.27 | 0.34-4.70 | .721 |
| Osteonecrosis, lifetime | 136/710 | 18.3 | 18.8 | 0.99 | 0.60-1.62 | .957 |
| Pediatric SS or Sβ0phenotype population (<18 y old, n = 1041) | ||||||
| TRV >2.5 m/s† | 26/112 | 27.8 | 19.1 | 1.67 | 0.63-4.43 | .297 |
| TRV >3 m/s† | 2/112 | 2.8 | 1.5 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 324/794 | 49.8 | 37.3 | 1.47 | 1.05-2.06 | .003 |
| Leg ulcer, lifetime | 38/1041 | 4.2 | 3.5 | 1.28 | 0.63-2.62 | .493 |
| Priapism, lifetime§ | 45/503 | 9.1 | 9.0 | 0.84 | 0.43-1.67 | .625 |
| Stroke, lifetime | 10/1041 | 0.7 | 1.1 | 0.49 | 0.10-2.42 | .381 |
| Osteonecrosis, lifetime | 73/1041 | 9.4 | 6.1 | 1.25 | 0.73-2.15 | .408 |