The diagnostic work-up of adults with T-cell ALL: essential tests and tests that are currently research based
| Essential tests required for routine diagnosis and management of T-cell ALL . | Non-essential tests currently being investigated within clinical trials in T-cell ALL . |
|---|---|
| Immunophenotyping | |
| Determination of pre-T/pro-T, cortical, and mature T-cell phenotype | Determination of ETP subtype |
| Oncogenetic analysis | |
| Identification of patients with a complex karyotype | NOTCH1/FBXW7 mutations |
| PTEN/NK-RAS mutations | |
| JAK/STAT mutations | |
| NUP21-ABL1 fusion | |
| IL-7 receptor mutations | |
| Molecular assessment for identification of T-cell receptor rearrangement for MRD monitoring |
| Essential tests required for routine diagnosis and management of T-cell ALL . | Non-essential tests currently being investigated within clinical trials in T-cell ALL . |
|---|---|
| Immunophenotyping | |
| Determination of pre-T/pro-T, cortical, and mature T-cell phenotype | Determination of ETP subtype |
| Oncogenetic analysis | |
| Identification of patients with a complex karyotype | NOTCH1/FBXW7 mutations |
| PTEN/NK-RAS mutations | |
| JAK/STAT mutations | |
| NUP21-ABL1 fusion | |
| IL-7 receptor mutations | |
| Molecular assessment for identification of T-cell receptor rearrangement for MRD monitoring |
IL-7, interleukin 7.