Table 3.

Biomarker correlation with response and PFS

ResponsePD-L1 staining
NegativeWeakly +Positive
N = 10 (%)N = 6 (%)N = 13 (%)P value
sCR/CR/VGPR 0/0/2 (20) 0 1/1/5 (54) .06 
PFS, median, mo (95% CI) 17.4 17.5 NR  
10.6-18.4 6.4-17.5 3.7, NR  
ResponsePD-L1 staining
NegativeWeakly +Positive
N = 10 (%)N = 6 (%)N = 13 (%)P value
sCR/CR/VGPR 0/0/2 (20) 0 1/1/5 (54) .06 
PFS, median, mo (95% CI) 17.4 17.5 NR  
10.6-18.4 6.4-17.5 3.7, NR  
PD-1/CD staining
CD3+/PD1+CD3+/PD1−CD3−/PD1−
N = 6 (%)N = 10 (%)N = 22 (%)
sCR/CR/VGPR 0 0/1/4 (50) 3/0/2 (23)  
PFS, median, mo (95% CI) 6.3 16.5 17.5  
2.6, NR 10.6, NR 11.7, NR .05 
PD-1/CD staining
CD3+/PD1+CD3+/PD1−CD3−/PD1−
N = 6 (%)N = 10 (%)N = 22 (%)
sCR/CR/VGPR 0 0/1/4 (50) 3/0/2 (23)  
PFS, median, mo (95% CI) 6.3 16.5 17.5  
2.6, NR 10.6, NR 11.7, NR .05 
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