Most common adverse events in the intent to treat population
| . | No. of patients (%) . | |
|---|---|---|
| Event . | Any grade . | > Grade 3 . |
| Hematologic adverse events | ||
| Neutropenia | 28 (58) | 20 (42) |
| Anemia | 26 (45) | 10 (21) |
| Thrombocytopenia | 24 (50) | 6 (13) |
| Lymphopenia | 14 (29) | 7 (15) |
| Nonhematologic adverse events | ||
| Fatigue | 35 (73) | 7 (15) |
| Hyperglycemia | 27 (56) | 10 (21) |
| Dizziness | 19 (40) | 2 (4) |
| Constipation | 17 (35) | 0 |
| Upper respiratory tract infection | 16 (33) | 6 (13) |
| Influenza A | 4 (8) | 4 (8) |
| Respiratory syncytial virus | 1 (2) | 1 (2) |
| Rhinovirus | 3 (6) | 1 (2) |
| Dyspnea | 15 (31) | 1 (2) |
| Peripheral edema | 15 (31) | 0 |
| Muscle spasm | 13 (27) | 1 (2) |
| Rash | 12 (25) | 4 (8) |
| Diarrhea | 11 (23) | 0 |
| Infection | 11 (23) | 2 (4) |
| Pneumonia | 10 (21) | 7 (15) |
| Nausea | 10 (21) | |
| Hypotension | 9 (19) | 1 (2) |
| Peripheral neuropathy | 6 (13) | 0 |
| Arrhythmia | 5 (10) | 2 (4) |
| Immune-mediated events | ||
| Pneumonitis | 6 (13) | 1 (2) |
| Hypothyroidism | 5 (10) | 2 (4) |
| Adrenal insufficiency | 2 (4) | 1 (2) |
| Hepatitis | 2 (4) | 1 (2) |
| Vitiligo | 1 (2) | 0 |
| . | No. of patients (%) . | |
|---|---|---|
| Event . | Any grade . | > Grade 3 . |
| Hematologic adverse events | ||
| Neutropenia | 28 (58) | 20 (42) |
| Anemia | 26 (45) | 10 (21) |
| Thrombocytopenia | 24 (50) | 6 (13) |
| Lymphopenia | 14 (29) | 7 (15) |
| Nonhematologic adverse events | ||
| Fatigue | 35 (73) | 7 (15) |
| Hyperglycemia | 27 (56) | 10 (21) |
| Dizziness | 19 (40) | 2 (4) |
| Constipation | 17 (35) | 0 |
| Upper respiratory tract infection | 16 (33) | 6 (13) |
| Influenza A | 4 (8) | 4 (8) |
| Respiratory syncytial virus | 1 (2) | 1 (2) |
| Rhinovirus | 3 (6) | 1 (2) |
| Dyspnea | 15 (31) | 1 (2) |
| Peripheral edema | 15 (31) | 0 |
| Muscle spasm | 13 (27) | 1 (2) |
| Rash | 12 (25) | 4 (8) |
| Diarrhea | 11 (23) | 0 |
| Infection | 11 (23) | 2 (4) |
| Pneumonia | 10 (21) | 7 (15) |
| Nausea | 10 (21) | |
| Hypotension | 9 (19) | 1 (2) |
| Peripheral neuropathy | 6 (13) | 0 |
| Arrhythmia | 5 (10) | 2 (4) |
| Immune-mediated events | ||
| Pneumonitis | 6 (13) | 1 (2) |
| Hypothyroidism | 5 (10) | 2 (4) |
| Adrenal insufficiency | 2 (4) | 1 (2) |
| Hepatitis | 2 (4) | 1 (2) |
| Vitiligo | 1 (2) | 0 |