The equation of GLM and the interpretation of parameter and intercept are described in supplemental Data. Best GLM was generated by backward stepwise selection (supplemental Table 1), including all the variables examined by univariable analyses in Table 2. GLM-2 was generated by backward stepwise selection (detailed in supplemental Table 1) by excluding iNKT cell frequency.

SE, standard error.

P < .05 indicates factors with statistically significant prognostic contribution, as calculated by backward stepwise selection, detailed in supplemental Table 1. P values were obtained by means of 2-tailed Z test performed by using R software.

iNKT cell frequency: selected prognostic factor; square root transformation was adopted for iNKT cell frequency to account for the small positive values of iNKT cell frequencies among total T cells.

CD38 expression on CLL is a selected prognostic factor.