Univariable analysis defines the prognostic values for CLL of currently used biomarkers, iNKT cells, and CD1d expression
| Prognostic factor . | No. of patients tested . | P* . | Ordering† . |
|---|---|---|---|
| Rai at diagnosis | 60 | .157 | P>S |
| ZAP-70‡ | 59 | .097 | P>S |
| Chromosomal aberration scoreठ| 63 | .034 | P>S |
| FISH del 17p | .243 | P>S | |
| Trisomy 12 | .090 | P>S | |
| FISH del 11q | .083 | P>S | |
| iNKT cell counts‡ | 48 | .050 | P<S |
| CD1d expression‡ | 64 | .032 | P>S |
| IGHV unmutated status | 58 | .003 | P>S |
| iNKT cell frequency‡ | 50 | .003 | P<S |
| CD38‡ | 65 | .0001 | P>S |
| Prognostic factor . | No. of patients tested . | P* . | Ordering† . |
|---|---|---|---|
| Rai at diagnosis | 60 | .157 | P>S |
| ZAP-70‡ | 59 | .097 | P>S |
| Chromosomal aberration scoreठ| 63 | .034 | P>S |
| FISH del 17p | .243 | P>S | |
| Trisomy 12 | .090 | P>S | |
| FISH del 11q | .083 | P>S | |
| iNKT cell counts‡ | 48 | .050 | P<S |
| CD1d expression‡ | 64 | .032 | P>S |
| IGHV unmutated status | 58 | .003 | P>S |
| iNKT cell frequency‡ | 50 | .003 | P<S |
| CD38‡ | 65 | .0001 | P>S |
The distribution of each prognostic factor in patients with stable disease (S) vs progressive disease (P) was compared by Wilcoxon tests.
FISH, fluorescent in situ hybridization.
P values < .05 indicate statistically significant difference between patients with progressive disease and those with stable disease.
P>S tested the hypothesis with prognostic factor values higher among patients with progressive disease than among patients with stable disease; P<S tested the hypothesis with prognostic factor values lower among patients with progressive disease than among patients with stable disease.
Each variable was evaluated as continuous.
Chromosomal aberration score was calculated as the sum of total chromosomal aberration numbers per patient.