Light-chain variable region gene distribution in localized amyloidosis according to organ involvement
| Ig V gene . | Skin, N = 36 . | Lung parenchyma, N = 31 . | Urothelial, N = 18 . | Gastrointestinal, N = 17 . |
|---|---|---|---|---|
| KV1-33 | 2 (6%) | 1 (3%) | 0 | 2 (11%) |
| Other κ | 5 (14%) | 5 (16%) | 0 | 2 (11%) |
| KV1-other | 1 (3%) | 0 | 0 | 0 |
| KV4-01 | 1 (3%) | 1 (3%) | 2 (11%) | 1 (5%) |
| KV1-39 | 3 (8%) | 0 | 0 | 0 |
| KV1-05 | 3 (8%) | 1 (3%) | 0 | 0 |
| KV3-15 | 1 (3%) | 1 (3%) | 2 (11%) | 1 (5%) |
| KV1-16 | 1 (3%) | 0 | 0 | 0 |
| KV3-20 | 2 (6%) | 5 (16%) | 1 (6%) | 2 (11%) |
| Other λ | 6 (17%) | 8 (26%) | 5 (28%) | 1 (5%) |
| LV6-57 | 0 | 3 (10%) | 2 (11%) | 0 |
| LV3-01 | 2 (6%) | 1 (3%) | 0 | 1 (5%) |
| LV2-14* | 2 (6%) | 0 | 2 (11%) | 5 (26%) |
| LV1-44 | 1 (3%) | 1 (3%) | 1 (6%) | 1 (1%) |
| LV3-21 | 2 (6%) | 0 | 0 | 1 (5%) |
| LV1-51 | 1 (3%) | 2 (7%) | 0 | 1 (5%) |
| LV3-19 | 0 | 1 (3%) | 0 | 0 |
| LV1-47 | 1 (3%) | 0 | 1 (6%) | 0 |
| LV2-08 | 0 | 0 | 1 (6%) | 0 |
| LV2-23 | 1 (3%) | 0 | 0 | 0 |
| LV1-40 | 1 (3%) | 1 (3%) | 1 (6%) | 0 |
| No gene/family | 1 (3%) | 3 (10%) | 4 (22%) | 1 (5%) |
| Codeposited heavy chain | 2 (6%) | 1 (3%) | 0 | 2 (11%) |
| Ig V gene . | Skin, N = 36 . | Lung parenchyma, N = 31 . | Urothelial, N = 18 . | Gastrointestinal, N = 17 . |
|---|---|---|---|---|
| KV1-33 | 2 (6%) | 1 (3%) | 0 | 2 (11%) |
| Other κ | 5 (14%) | 5 (16%) | 0 | 2 (11%) |
| KV1-other | 1 (3%) | 0 | 0 | 0 |
| KV4-01 | 1 (3%) | 1 (3%) | 2 (11%) | 1 (5%) |
| KV1-39 | 3 (8%) | 0 | 0 | 0 |
| KV1-05 | 3 (8%) | 1 (3%) | 0 | 0 |
| KV3-15 | 1 (3%) | 1 (3%) | 2 (11%) | 1 (5%) |
| KV1-16 | 1 (3%) | 0 | 0 | 0 |
| KV3-20 | 2 (6%) | 5 (16%) | 1 (6%) | 2 (11%) |
| Other λ | 6 (17%) | 8 (26%) | 5 (28%) | 1 (5%) |
| LV6-57 | 0 | 3 (10%) | 2 (11%) | 0 |
| LV3-01 | 2 (6%) | 1 (3%) | 0 | 1 (5%) |
| LV2-14* | 2 (6%) | 0 | 2 (11%) | 5 (26%) |
| LV1-44 | 1 (3%) | 1 (3%) | 1 (6%) | 1 (1%) |
| LV3-21 | 2 (6%) | 0 | 0 | 1 (5%) |
| LV1-51 | 1 (3%) | 2 (7%) | 0 | 1 (5%) |
| LV3-19 | 0 | 1 (3%) | 0 | 0 |
| LV1-47 | 1 (3%) | 0 | 1 (6%) | 0 |
| LV2-08 | 0 | 0 | 1 (6%) | 0 |
| LV2-23 | 1 (3%) | 0 | 0 | 0 |
| LV1-40 | 1 (3%) | 1 (3%) | 1 (6%) | 0 |
| No gene/family | 1 (3%) | 3 (10%) | 4 (22%) | 1 (5%) |
| Codeposited heavy chain | 2 (6%) | 1 (3%) | 0 | 2 (11%) |
Other κ/λ: includes rare κ genes (KV2-28, 30, 38, KV3-01, 07, 11, KV6-21, rare KV1 excluded); rare λ genes (LV1-01, 36, 52, 57, LV2-08, 11, 18, LV3-09, 10, 20, 25, LV4-60, 69, and LV10-54); cases where only family could be determined; and cases that no gene or family could be determined. KV1-other: includes rare KV1-genes (KV1-02, 06, 08, 09, 12, 13, 17, and 27).
P < .01.