Demographics and clinical characteristics of patients
| Characteristic (N = 821) . | ALS (N = 701) . | ALL (N = 120) . |
|---|---|---|
| Male | 445 (64%) | 46 (38%) |
| Age (y), median (range) | 63 (36-89) | 60 (32-86) |
| Seen at Mayo within 90 d of diagnosis | 530 (76%) | 61 (50%) |
| Circulating monoclonal protein in the serum or urine* | ||
| κ | 187 (27%) | |
| IgG | 270 (39%) | |
| IgA | 40 (6%) | |
| IgM | 42 (6%) | |
| IgD | 5 (0.7%) | |
| Light chain only | 284 (41%) | |
| Biclonal | 5 (0.7%) | |
| No circulating monoclonal protein | 18 (3%) | |
| No data on monoclonal protein | 37 (5%) | |
| Organ involvement | ||
| Cardiac | 457 (65%) | 0 |
| Mayo 2004 cardiac stage† | NA | |
| I | 76 (19%) | |
| II | 150 (38%) | |
| III | 169 (43%) | |
| Renal | 357 (51%) | 0 |
| Renal stage‡ | NA | |
| I | 64 (42%) | |
| II | 70 (46%) | |
| III | 17 (12%) | |
| Peripheral and autonomic nervous system | 112 (16%) | 0 |
| Hepatic | 56 (8%) | 0 |
| Gastrointestinal system | 174 (25%) | 18 (16%) |
| Skin | 23 (3%) | 36 (30%) |
| Other soft tissue | 100 (14%) | 37 (31%) |
| Lung parenchymal | 43 (6%) | 31 (26%) |
| Lymph nodes | 13 (2%) | 1 (0.8%) |
| Bladder or ureter | 5 (1%) | 18 (15%) |
| Tracheobronchial | 0 | 5 (4%) |
| Characteristic (N = 821) . | ALS (N = 701) . | ALL (N = 120) . |
|---|---|---|
| Male | 445 (64%) | 46 (38%) |
| Age (y), median (range) | 63 (36-89) | 60 (32-86) |
| Seen at Mayo within 90 d of diagnosis | 530 (76%) | 61 (50%) |
| Circulating monoclonal protein in the serum or urine* | ||
| κ | 187 (27%) | |
| IgG | 270 (39%) | |
| IgA | 40 (6%) | |
| IgM | 42 (6%) | |
| IgD | 5 (0.7%) | |
| Light chain only | 284 (41%) | |
| Biclonal | 5 (0.7%) | |
| No circulating monoclonal protein | 18 (3%) | |
| No data on monoclonal protein | 37 (5%) | |
| Organ involvement | ||
| Cardiac | 457 (65%) | 0 |
| Mayo 2004 cardiac stage† | NA | |
| I | 76 (19%) | |
| II | 150 (38%) | |
| III | 169 (43%) | |
| Renal | 357 (51%) | 0 |
| Renal stage‡ | NA | |
| I | 64 (42%) | |
| II | 70 (46%) | |
| III | 17 (12%) | |
| Peripheral and autonomic nervous system | 112 (16%) | 0 |
| Hepatic | 56 (8%) | 0 |
| Gastrointestinal system | 174 (25%) | 18 (16%) |
| Skin | 23 (3%) | 36 (30%) |
| Other soft tissue | 100 (14%) | 37 (31%) |
| Lung parenchymal | 43 (6%) | 31 (26%) |
| Lymph nodes | 13 (2%) | 1 (0.8%) |
| Bladder or ureter | 5 (1%) | 18 (15%) |
| Tracheobronchial | 0 | 5 (4%) |