GVHD response to BV by dose level, organ involvement, and severity
| . | No. (%) . | ||
|---|---|---|---|
| CR . | VGPR . | OR . | |
| Drug dose | |||
| 0.6 mg/kg weekly × 3 | 1/3 (33) | 1/3 (33) | 2/3 (67) |
| 0.9 mg/kg weekly × 3 | 0/3 (0) | 0/3 (0) | 0/3 (0) |
| 0.6 mg/kg every other week × 4 | 2/10 (20) | 1/10 (10) | 3/10 (30) |
| 0.8 mg/kg every other week × 4 | 2/18 (11) | 6/18 (33) | 8/18 (44) |
| Overall | 5/34 (15) | 8/34 (24) | 13/34 (38) |
| Organs involved | |||
| Skin | 2/18 (11) | 3/18 (17) | 5/18 (28) |
| Intestine | 3/24 (12) | 7/24 (29) | 10/24 (42) |
| Liver | 2/11 (18) | 3/11 (27) | 5/11 (45) |
| GVHD grade at enrollment | |||
| II | 3/10 (30) | 1/10 (10) | 4/10 (40) |
| III | 2/22 (9) | 7/22 (32) | 9/22 (41) |
| IV | 0/2 (0) | 0/2 (0) | 0/2 (0) |
| . | No. (%) . | ||
|---|---|---|---|
| CR . | VGPR . | OR . | |
| Drug dose | |||
| 0.6 mg/kg weekly × 3 | 1/3 (33) | 1/3 (33) | 2/3 (67) |
| 0.9 mg/kg weekly × 3 | 0/3 (0) | 0/3 (0) | 0/3 (0) |
| 0.6 mg/kg every other week × 4 | 2/10 (20) | 1/10 (10) | 3/10 (30) |
| 0.8 mg/kg every other week × 4 | 2/18 (11) | 6/18 (33) | 8/18 (44) |
| Overall | 5/34 (15) | 8/34 (24) | 13/34 (38) |
| Organs involved | |||
| Skin | 2/18 (11) | 3/18 (17) | 5/18 (28) |
| Intestine | 3/24 (12) | 7/24 (29) | 10/24 (42) |
| Liver | 2/11 (18) | 3/11 (27) | 5/11 (45) |
| GVHD grade at enrollment | |||
| II | 3/10 (30) | 1/10 (10) | 4/10 (40) |
| III | 2/22 (9) | 7/22 (32) | 9/22 (41) |
| IV | 0/2 (0) | 0/2 (0) | 0/2 (0) |
OR, overall response.