Table 2.

Risk factors for mortality and progression among patients with MM

PFSOS
Crude HR (95% CI)PAdjusted* HR (95% CI)PCrude HR (95% CI)PAdjusted* HR (95% CI)P
Low let-7b 1.78 (1.21-2.60) .003† 1.90 (1.22-2.94) .004 4.57 (1.90-10.97) .001† 2.83 (1.07-7.50) .036 
Low let-7c 1.22 (0.84-1.78) .302   2.28 (1.04-4.99) .039   
Low let-7e 1.73 (1.19-2.53) .005† 2.01 (1.30-3.11) .002 2.39 (1.09-5.24) .030   
Low miR-106a 1.90 (1.30-2.78) .001† 2.34 (1.52-3.61) <.001 2.67 (1.21-5.88) .015   
Low miR-106b 2.52 (1.72-3.69) <.001† 3.54 (2.21-5.68) <.001 2.76 (1.25-6.10) .012   
Low miR-10b 1.23 (0.85-1.80) .273   1.82 (0.83-3.98) .133   
Low miR-125a 1.28 (0.88-1.86) .203   2.31 (1.05-5.08) .037   
Low miR-125b 1.02 (0.70-1.49) .906   1.27 (0.60-2.72) .533   
Low miR-155 1.64 (1.12-2.40) .011† 1.76 (1.15-2.69) .009 3.19 (1.42-7.14) .005† 2.41 (0.96-6.05) .061 
Low miR-15a 1.37 (0.94-2.00) .101   2.27 (1.02-5.06) .046   
Low miR-16 1.86 (1.27-2.72) .001† 2.21 (1.41-3.47) .001 2.37 (1.09-5.17) .030   
Low miR-17 1.83 (1.25-2.67) .002† 2.29 (1.48-3.55) <.001 2.21 (1.01-4.83) .046   
Low miR-181a 1.45 (0.99-2.12) .054   2.15 (1.00-4.63) .051   
Low miR-18a 2.01 (1.37-2.94) <.001† 2.76 (1.79-4.26) <.001 4.62 (1.85-11.50) .001† 4.52 (1.57-12.98) .005 
Low miR-19a 0.13 (0.02-0.99) .049 ‡  ‡ .990   
Low miR-19b 0.83 (0.56-1.22) .335   0.48 (0.22-1.03) .060   
Low miR-20a 2.00 (1.37-2.92) <.001† 2.31 (1.52-3.53) <.001 2.91 (1.29-6.54) .010   
Low miR-21 1.53 (1.05-2.23) .028   1.88 (0.88-4.06) .106   
Low miR-223 1.33 (0.91-1.94) .147   1.77 (0.83-3.76) .140   
Low miR-25 1.20 (0.82-1.76) .344   2.56 (1.16-5.65) .020   
Low miR-744 1.32 (0.91-1.93) .144   2.10 (0.97-4.53) .059   
Low miR-92a 1.39 (0.95-2.02) .089   2.15 (1.00-4.65) .051   
PFSOS
Crude HR (95% CI)PAdjusted* HR (95% CI)PCrude HR (95% CI)PAdjusted* HR (95% CI)P
Low let-7b 1.78 (1.21-2.60) .003† 1.90 (1.22-2.94) .004 4.57 (1.90-10.97) .001† 2.83 (1.07-7.50) .036 
Low let-7c 1.22 (0.84-1.78) .302   2.28 (1.04-4.99) .039   
Low let-7e 1.73 (1.19-2.53) .005† 2.01 (1.30-3.11) .002 2.39 (1.09-5.24) .030   
Low miR-106a 1.90 (1.30-2.78) .001† 2.34 (1.52-3.61) <.001 2.67 (1.21-5.88) .015   
Low miR-106b 2.52 (1.72-3.69) <.001† 3.54 (2.21-5.68) <.001 2.76 (1.25-6.10) .012   
Low miR-10b 1.23 (0.85-1.80) .273   1.82 (0.83-3.98) .133   
Low miR-125a 1.28 (0.88-1.86) .203   2.31 (1.05-5.08) .037   
Low miR-125b 1.02 (0.70-1.49) .906   1.27 (0.60-2.72) .533   
Low miR-155 1.64 (1.12-2.40) .011† 1.76 (1.15-2.69) .009 3.19 (1.42-7.14) .005† 2.41 (0.96-6.05) .061 
Low miR-15a 1.37 (0.94-2.00) .101   2.27 (1.02-5.06) .046   
Low miR-16 1.86 (1.27-2.72) .001† 2.21 (1.41-3.47) .001 2.37 (1.09-5.17) .030   
Low miR-17 1.83 (1.25-2.67) .002† 2.29 (1.48-3.55) <.001 2.21 (1.01-4.83) .046   
Low miR-181a 1.45 (0.99-2.12) .054   2.15 (1.00-4.63) .051   
Low miR-18a 2.01 (1.37-2.94) <.001† 2.76 (1.79-4.26) <.001 4.62 (1.85-11.50) .001† 4.52 (1.57-12.98) .005 
Low miR-19a 0.13 (0.02-0.99) .049 ‡  ‡ .990   
Low miR-19b 0.83 (0.56-1.22) .335   0.48 (0.22-1.03) .060   
Low miR-20a 2.00 (1.37-2.92) <.001† 2.31 (1.52-3.53) <.001 2.91 (1.29-6.54) .010   
Low miR-21 1.53 (1.05-2.23) .028   1.88 (0.88-4.06) .106   
Low miR-223 1.33 (0.91-1.94) .147   1.77 (0.83-3.76) .140   
Low miR-25 1.20 (0.82-1.76) .344   2.56 (1.16-5.65) .020   
Low miR-744 1.32 (0.91-1.93) .144   2.10 (0.97-4.53) .059   
Low miR-92a 1.39 (0.95-2.02) .089   2.15 (1.00-4.65) .051   

CI, confidence interval; HR, hazard ratio.

*

Adjusted for ISS stage, del(17q), and t(4;14).

†

Significance by using Benjamini-Hochberg correction (corrected significance level = .020 for PFS and .006 for OS).

‡

Data did not converge.

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