The top 20 enriched gene signatures determined by GSEA for GFP+ BM-MNCs isolated from mice given Fzr1-deficient B-ALL cells relative to those from mice given Fzr1-intact B-ALL cells
| Gene set (reactome) . | NES . | P . | FDR . |
|---|---|---|---|
| Toll-like receptor 4 cascade | 2.08 | <.001 | 0.006 |
| MYD88 cascade | 1.89 | .002 | 0.050 |
| Activated TLR4 signaling | 1.82 | <.001 | 0.083 |
| Metal ion SLC transporters | 1.82 | .006 | 0.063 |
| G2-M checkpoints | 1.72 | .002 | 0.163 |
| Late phase of HIV life cycle | 1.71 | <.001 | 0.151 |
| Toll-like receptor 9 cascade | 1.71 | .006 | 0.133 |
| Vpr-mediated nuclear import of PICs | 1.68 | <.001 | 0.145 |
| snRNP assembly | 1.68 | .006 | 0.133 |
| Transport of ribonucleoproteins into the host nucleus | 1.64 | .017 | 0.186 |
| Nuclear import of rev protein | 1.62 | .024 | 0.190 |
| Transport of mature mRNA derived from an intron containing transcript | 1.61 | .006 | 0.198 |
| Rev mediated nuclear export of HIV1 RNA | 1.61 | .017 | 0.183 |
| NEP/NS2 interacts with the cellular export machinery | 1.61 | .028 | 0.172 |
| Activation of ATR in response to replication stress | 1.60 | .028 | 0.167 |
| Transcription of the HIV genome | 1.60 | .004 | 0.160 |
| Mitotic prometaphase | 1.59 | .004 | 0.163 |
| Glycogen breakdown glycogenolysis | 1.58 | .025 | 0.177 |
| Metabolism of RNA | 1.54 | .015 | 0.227 |
| HIV life cycle | 1.52 | .011 | 0.244 |
| Gene set (reactome) . | NES . | P . | FDR . |
|---|---|---|---|
| Toll-like receptor 4 cascade | 2.08 | <.001 | 0.006 |
| MYD88 cascade | 1.89 | .002 | 0.050 |
| Activated TLR4 signaling | 1.82 | <.001 | 0.083 |
| Metal ion SLC transporters | 1.82 | .006 | 0.063 |
| G2-M checkpoints | 1.72 | .002 | 0.163 |
| Late phase of HIV life cycle | 1.71 | <.001 | 0.151 |
| Toll-like receptor 9 cascade | 1.71 | .006 | 0.133 |
| Vpr-mediated nuclear import of PICs | 1.68 | <.001 | 0.145 |
| snRNP assembly | 1.68 | .006 | 0.133 |
| Transport of ribonucleoproteins into the host nucleus | 1.64 | .017 | 0.186 |
| Nuclear import of rev protein | 1.62 | .024 | 0.190 |
| Transport of mature mRNA derived from an intron containing transcript | 1.61 | .006 | 0.198 |
| Rev mediated nuclear export of HIV1 RNA | 1.61 | .017 | 0.183 |
| NEP/NS2 interacts with the cellular export machinery | 1.61 | .028 | 0.172 |
| Activation of ATR in response to replication stress | 1.60 | .028 | 0.167 |
| Transcription of the HIV genome | 1.60 | .004 | 0.160 |
| Mitotic prometaphase | 1.59 | .004 | 0.163 |
| Glycogen breakdown glycogenolysis | 1.58 | .025 | 0.177 |
| Metabolism of RNA | 1.54 | .015 | 0.227 |
| HIV life cycle | 1.52 | .011 | 0.244 |
Bold type indicates 3 gene sets related to mitosis or DDR.
FDR, false-discovery rate; NES, normalized enrichment score.