Table 3

Cox multivariate analysis of high sIgM and molecular prognostic parameters associated with TTFT

SEPHR (95% CI)
sIgM MFI > 50 0.223 .015 1.718 (1.109-2.662) 
IGHV ≥ 98% 0.227 .004 1.917 (1.228-2.993) 
+12/FISH 0.223 .001 2.099 (1.355-3.251) 
del(11q) 0.330 .048 1.918 (1.005-3.663) 
del(17p)/NOTCH1ΔCT* 0.306 .493 1.233 (0.678-2.245) 
SEPHR (95% CI)
sIgM MFI > 50 0.223 .015 1.718 (1.109-2.662) 
IGHV ≥ 98% 0.227 .004 1.917 (1.228-2.993) 
+12/FISH 0.223 .001 2.099 (1.355-3.251) 
del(11q) 0.330 .048 1.918 (1.005-3.663) 
del(17p)/NOTCH1ΔCT* 0.306 .493 1.233 (0.678-2.245) 

Number of cases entered in the multivariate analysis = 184; number of events = 108.

Abbreviations are explained in Table 1.

*

Because no difference in TTFT was observed between patients with NOTCH1ΔCT and del(17p), these lesions were pooled together for multivariate survival analyses (also refer to supplemental Table 3).