Thiol isomerases in thrombus formation
| Thrombosis model . | Mode of inhibition of TI . | Effect on thrombus formation . | Reference . |
|---|---|---|---|
| Laser-induced injury cremaster arteriole | Anti-PDI antibody (RL90) | Minimal platelet accumulation No fibrin generation | 67 |
| Ligation Model | Anti-PDI antibody | ∼70% reduction in fibrin formation at 30 minutes | 68 |
| Laser-induced injury cremaster arteriole | Quercetin-3-rutinoside, 0.5 μg/kg | Near absence of platelet accumulation and fibrin generation | 69 |
| FeCl3-induced injury | Quercetin-3-rutinoside | 2.2-fold increase in occlusion time | 69 |
| Laser-induced injury cremaster arteriole | Platelet/MK-specific PDI null | ∼75% inhibition of peak platelet accumulation | 46 |
| FeCl3-induced carotid injury | Platelet/MK-specific PDI null | Two-fold increase in occlusion time | 9 |
| FeCl3-induced carotid injury | Mice expressing a mutant PDI (CGHC/SGHS) | ∼1.5-fold increase in occlusion time | 9 |
| FeCl3-induced carotid injury | Anti-ERp57 antibody (Mab1) | Approximately threefold increase in occlusion time | 57 |
| Laser-induced injury cremaster arteriole | Anti-ERp57 antibody | ∼80% reduction in platelet accumulation | 56 |
| FeCl3-induced carotid injury | Platelet/MK-specific ERp57 null | ∼1.9-fold increase in occlusion time | 71 |
| Laser-induced injury cremaster arteriole | Anti-ERp5 antibody | 70% decrease in platelet accumulation | 45 |
| 62% decrease in fibrin generation |
| Thrombosis model . | Mode of inhibition of TI . | Effect on thrombus formation . | Reference . |
|---|---|---|---|
| Laser-induced injury cremaster arteriole | Anti-PDI antibody (RL90) | Minimal platelet accumulation No fibrin generation | 67 |
| Ligation Model | Anti-PDI antibody | ∼70% reduction in fibrin formation at 30 minutes | 68 |
| Laser-induced injury cremaster arteriole | Quercetin-3-rutinoside, 0.5 μg/kg | Near absence of platelet accumulation and fibrin generation | 69 |
| FeCl3-induced injury | Quercetin-3-rutinoside | 2.2-fold increase in occlusion time | 69 |
| Laser-induced injury cremaster arteriole | Platelet/MK-specific PDI null | ∼75% inhibition of peak platelet accumulation | 46 |
| FeCl3-induced carotid injury | Platelet/MK-specific PDI null | Two-fold increase in occlusion time | 9 |
| FeCl3-induced carotid injury | Mice expressing a mutant PDI (CGHC/SGHS) | ∼1.5-fold increase in occlusion time | 9 |
| FeCl3-induced carotid injury | Anti-ERp57 antibody (Mab1) | Approximately threefold increase in occlusion time | 57 |
| Laser-induced injury cremaster arteriole | Anti-ERp57 antibody | ∼80% reduction in platelet accumulation | 56 |
| FeCl3-induced carotid injury | Platelet/MK-specific ERp57 null | ∼1.9-fold increase in occlusion time | 71 |
| Laser-induced injury cremaster arteriole | Anti-ERp5 antibody | 70% decrease in platelet accumulation | 45 |
| 62% decrease in fibrin generation |