Table 1

Upper bounds on the half-removal time

Dose, μgRemoval rate (γ), days−1Half-removal time (t1/2), daysSource
350 1.2773 0.54267 Krzyzanski et al (Figure 2)17  
375 0.98577 0.70315 Wang et al (Figure 7)18  
750 1.0917 0.6349 Wang et al (Figure 7)18  
Dose, μgRemoval rate (γ), days−1Half-removal time (t1/2), daysSource
350 1.2773 0.54267 Krzyzanski et al (Figure 2)17  
375 0.98577 0.70315 Wang et al (Figure 7)18  
750 1.0917 0.6349 Wang et al (Figure 7)18  

γ Values presented here are the lower bounds calculated from inequality 2 using the data presented in Figure 1. From these lower bounds, an upper bound on the half-removal time can be calculated using t1/2 = ln2/γ. The average lower bound on γ was 1.1183 days−1, giving an upper bound of 0.6198 days, or 14.876 hours, for the half-removal time t1/2.