Table 1 Summary of genomic alterations... | American Society of Hematology

Table 1

Summary of genomic alterations identified in Ph-like B-ALL cases

Specimen ID	Kinase fusion	Kinase CNA/sequence mutation	RAS pathway	Other lesion	IKZF1 deletion or mutation	PAX5 deletion or mutation	EBF1 alteration	CDKN2A/B deletion
ALL1	PAX5-JAK2	Unknown			Deletion	No	Yes	No
ALL2
ALL3	IGH-CRLF2	CRLF2 F232C*			Deletion (single exon deletion)	No	Yes	No
ALL4
ALL5	SSBP2-JAK2	Unknown			Deletion	No	No	Yes
ALL6
ALL7	RSCD1-ABL2	Unknown			Deletion	No	No	No
ALL8	IGH-EPOR		KRAS G12D		Deletion	Deletion and mutation	No	Yes
ALL11				CREBBP R1081fs ETV6 focal deletion	Deletion (single exon deletion)	No	No	Yes*
ALL12
ALL13	IGH-CRLF2
ALL14	P2RY8-CRLF2	JAK2 T875N			Deletion	Deletion	No	Yes
ALL15
ALL16	IGH-CRLF2	Unknown		PAX5-MEGF9			No
ALL17				FIP1L1-PDGFRA
ALL18

Specimen ID	Kinase fusion	Kinase CNA/sequence mutation	RAS pathway	Other lesion	IKZF1 deletion or mutation	PAX5 deletion or mutation	EBF1 alteration	CDKN2A/B deletion
ALL1	PAX5-JAK2	Unknown			Deletion	No	Yes	No
ALL2
ALL3	IGH-CRLF2	CRLF2 F232C*			Deletion (single exon deletion)	No	Yes	No
ALL4
ALL5	SSBP2-JAK2	Unknown			Deletion	No	No	Yes
ALL6
ALL7	RSCD1-ABL2	Unknown			Deletion	No	No	No
ALL8	IGH-EPOR		KRAS G12D		Deletion	Deletion and mutation	No	Yes
ALL11				CREBBP R1081fs ETV6 focal deletion	Deletion (single exon deletion)	No	No	Yes*
ALL12
ALL13	IGH-CRLF2
ALL14	P2RY8-CRLF2	JAK2 T875N			Deletion	Deletion	No	Yes
ALL15
ALL16	IGH-CRLF2	Unknown		PAX5-MEGF9			No
ALL17				FIP1L1-PDGFRA
ALL18

Summary of genomic alterations including kinase fusions, kinase mutation, and deletions in IKZF1, PAX5, EBF1, and CDKN2A/B in 16 Ph-like ALL patients.

Mutations that were detected only by the clinical sequencing assay.

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