Primary and secondary genetic events that can be identified by FISH
| Primary genetic events . | Secondary genetic events . | ||||
|---|---|---|---|---|---|
| IgH translocation . | Gene(s) . | Frequency (%) . | Deletion . | Gene(s) . | Frequency (%) . |
| t(4;14) | FGFR3/MMSET | 15 | 1p | CDKN2C, FAF1, FAM46C | 30 |
| t(6;14) | CCND3 | 4 | 6q | 33 | |
| t(11;14) | CCND1 | 20 | 8p | 25 | |
| t(14;16) | MAF | 4 | 13 | RB1, DIS3 | 44 |
| t(14;20) | MAFB | 1 | 11q | BIRC2/BIRC3 | 7 |
| 14q | TRAF3 | 38 | |||
| 16q | WWOX, CYLD | 35 | |||
| 17p | TP53 | 7 | |||
| Hyperdiploidy | Gain | ||||
| Trisomies of chromosomes 3, 5, 7, 9, 11, 15, 19, 21 | NA | 50 | 1q | CKS1B, ANP32E | 40 |
| Primary genetic events . | Secondary genetic events . | ||||
|---|---|---|---|---|---|
| IgH translocation . | Gene(s) . | Frequency (%) . | Deletion . | Gene(s) . | Frequency (%) . |
| t(4;14) | FGFR3/MMSET | 15 | 1p | CDKN2C, FAF1, FAM46C | 30 |
| t(6;14) | CCND3 | 4 | 6q | 33 | |
| t(11;14) | CCND1 | 20 | 8p | 25 | |
| t(14;16) | MAF | 4 | 13 | RB1, DIS3 | 44 |
| t(14;20) | MAFB | 1 | 11q | BIRC2/BIRC3 | 7 |
| 14q | TRAF3 | 38 | |||
| 16q | WWOX, CYLD | 35 | |||
| 17p | TP53 | 7 | |||
| Hyperdiploidy | Gain | ||||
| Trisomies of chromosomes 3, 5, 7, 9, 11, 15, 19, 21 | NA | 50 | 1q | CKS1B, ANP32E | 40 |