PK parameters following a 30-minute IV infusion of carfilzomib
| Parameter* . | Dose . | ||
|---|---|---|---|
| 20 mg/m2 (n = 25) . | 70 mg/m2 (n = 21) . | 88 mg/m2 (n = 5) . | |
| t1/2, h | 0.64 (0.193-1.29) | 0.950 (0.572-1.29)† | 0.848 (0.648-0.952)‡ |
| Cmax, ng/mL | 724 (42.9) | 2390 (30.7) | 3090 (27.3) |
| AUC0-last, ng × h/mL | 260 (27.6) | 1030 (20.5) | 1190 (29.1) |
| AUCinf, ng × h/mL | 260 (27.6) | 1030 (21.2)§ | 1140 (31.5)‡ |
| CL, L/h | 146 (30.4) | 131 (28.6)§ | 138 (34.3)‡ |
| Parameter* . | Dose . | ||
|---|---|---|---|
| 20 mg/m2 (n = 25) . | 70 mg/m2 (n = 21) . | 88 mg/m2 (n = 5) . | |
| t1/2, h | 0.64 (0.193-1.29) | 0.950 (0.572-1.29)† | 0.848 (0.648-0.952)‡ |
| Cmax, ng/mL | 724 (42.9) | 2390 (30.7) | 3090 (27.3) |
| AUC0-last, ng × h/mL | 260 (27.6) | 1030 (20.5) | 1190 (29.1) |
| AUCinf, ng × h/mL | 260 (27.6) | 1030 (21.2)§ | 1140 (31.5)‡ |
| CL, L/h | 146 (30.4) | 131 (28.6)§ | 138 (34.3)‡ |
AUC0-last, AUC from time 0 to last time measurable concentration; AUCinf, AUC from time 0 to infinity; CL, clearance; t1/2, terminal half-life.
Except for t1/2, which is expressed as median (minimum to maximum), all other parameters are shown as geometric mean (% coefficient of variation).
n = 16.
n = 4.
n = 17.