Diagnostic criteria for CNL
| CNL diagnostic criteria . |
|---|
| 1. PB WBC ≥25 × 109/L |
| Segmented neutrophils plus band forms ≥80% of WBCs |
| Neutrophil precursors (promyelocytes, myelocytes, and metamyelocytes) <10% of WBC |
| Myeloblasts rarely observed |
| Monocyte count <1 × 109/L |
| No dysgranulopoiesis |
| 2. Hypercellular BM |
| Neutrophil granulocytes increased in percentage and number |
| Neutrophil maturation appears normal |
| Myeloblasts <5% of nucleated cells |
| 3. Not meeting WHO criteria for BCR-ABL1+ CML, PV, ET, or PMF |
| 4. No rearrangement of PDGFRA, PDGFRB, or FGFR1, or PCM1-JAK2 |
| 5. Presence of CSF3R T618I or other activating CSF3R mutation |
| or |
| In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 mo), splenomegaly and no identifiable cause of reactive neutrophilia including absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies |
| CNL diagnostic criteria . |
|---|
| 1. PB WBC ≥25 × 109/L |
| Segmented neutrophils plus band forms ≥80% of WBCs |
| Neutrophil precursors (promyelocytes, myelocytes, and metamyelocytes) <10% of WBC |
| Myeloblasts rarely observed |
| Monocyte count <1 × 109/L |
| No dysgranulopoiesis |
| 2. Hypercellular BM |
| Neutrophil granulocytes increased in percentage and number |
| Neutrophil maturation appears normal |
| Myeloblasts <5% of nucleated cells |
| 3. Not meeting WHO criteria for BCR-ABL1+ CML, PV, ET, or PMF |
| 4. No rearrangement of PDGFRA, PDGFRB, or FGFR1, or PCM1-JAK2 |
| 5. Presence of CSF3R T618I or other activating CSF3R mutation |
| or |
| In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 mo), splenomegaly and no identifiable cause of reactive neutrophilia including absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies |