Reasons for upstaging and downstaging according to PET-CT compared with the RATHL stage
| Upstaging by PET-CT due to . | N (% of upstaged patients) . |
|---|---|
| Extranodal disease on PET-CT in the following sites | 118 (74.2) |
| Bone marrow | 92 |
| Lung | 11 |
| Liver | 2 |
| Pleura | 1 |
| Multiple organs | 12 |
| Nodal disease | 35 (22.0) |
| Normal sized nodes that were FDG avid below the diaphragm | 20 |
| Normal sized nodes that were FDG avid above the diaphragm | 7 |
| Splenic FDG avid foci | 7 |
| Both of the above | 1 |
| Difference in opinion | 6 (3.8) |
| Imaging findings interpreted differently by the local radiologist and the core laboratory PET CT reader or the treating clinician | 6 |
| Upstaging by PET-CT due to . | N (% of upstaged patients) . |
|---|---|
| Extranodal disease on PET-CT in the following sites | 118 (74.2) |
| Bone marrow | 92 |
| Lung | 11 |
| Liver | 2 |
| Pleura | 1 |
| Multiple organs | 12 |
| Nodal disease | 35 (22.0) |
| Normal sized nodes that were FDG avid below the diaphragm | 20 |
| Normal sized nodes that were FDG avid above the diaphragm | 7 |
| Splenic FDG avid foci | 7 |
| Both of the above | 1 |
| Difference in opinion | 6 (3.8) |
| Imaging findings interpreted differently by the local radiologist and the core laboratory PET CT reader or the treating clinician | 6 |
| Downstaging by PET-CT due to . | N (% of downstaged patients) . |
|---|---|
| Extranodal disease | 25 (33.8) |
| Lung | 11 |
| Bone marrow | 5 |
| Pleura | 3 |
| Bone | 1 |
| Adrenal gland | 1 |
| Liver | 2 |
| Small bowel | 1 |
| Multiple organs | 1 |
| Nodal disease | 34 (45.9) |
| Enlarged nodes that were not FDG avid below the diaphragm | 21 |
| Enlarged nodes that were not FDG avid above the diaphragm | 1 |
| Splenomegaly on CT, normal FDG uptake | 8 |
| Splenic lesion/s on ceCT not FDG avid | 3 |
| Splenomegaly on CT & enlarged nodes not FDG avid | 1 |
| Difference in opinion | 15 (20.3) |
| Imaging findings interpreted differently by the local radiologist and the core laboratory PET CT reader or the local radiologist and the treating clinician | 15 |
| Downstaging by PET-CT due to . | N (% of downstaged patients) . |
|---|---|
| Extranodal disease | 25 (33.8) |
| Lung | 11 |
| Bone marrow | 5 |
| Pleura | 3 |
| Bone | 1 |
| Adrenal gland | 1 |
| Liver | 2 |
| Small bowel | 1 |
| Multiple organs | 1 |
| Nodal disease | 34 (45.9) |
| Enlarged nodes that were not FDG avid below the diaphragm | 21 |
| Enlarged nodes that were not FDG avid above the diaphragm | 1 |
| Splenomegaly on CT, normal FDG uptake | 8 |
| Splenic lesion/s on ceCT not FDG avid | 3 |
| Splenomegaly on CT & enlarged nodes not FDG avid | 1 |
| Difference in opinion | 15 (20.3) |
| Imaging findings interpreted differently by the local radiologist and the core laboratory PET CT reader or the local radiologist and the treating clinician | 15 |