AEs during chemotherapy
| . | Induction (n = 90) . | Con #1 (n = 80) . | Con #2 (n = 65) . | Con #3 (n = 25) . | Con #4 (n = 8) . | Con #5 (n = 7) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | |
| Hematologic | ||||||||||||
| ANC | — | 98 | — | 42 | — | 98 | — | 39 | — | 100 | — | 43 |
| Platelet | — | 47 | — | 6 | — | 48 | — | 22 | — | 75 | — | 14 |
| Infection | ||||||||||||
| Febrile neutropenia | — | 11 | — | 1 | — | 6 | — | 0 | — | 0 | — | 0 |
| Bacteremia | — | 39 | — | 5 | — | 19 | — | 8 | — | 13 | — | 14 |
| Other infection | 13 | 1 | 4 | 0 | 5 | 0 | 12 | 0 | 13 | 0 | 0 | 0 |
| Lung infection | 6 | 1 | 0 | 0 | 2 | 0 | 12 | 0 | 0 | 0 | 0 | 0 |
| Soft tissue infection | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Others | 7 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 13 | 0 | 0 | 0 |
| . | Induction (n = 90) . | Con #1 (n = 80) . | Con #2 (n = 65) . | Con #3 (n = 25) . | Con #4 (n = 8) . | Con #5 (n = 7) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | Total . | G4 . | |
| Hematologic | ||||||||||||
| ANC | — | 98 | — | 42 | — | 98 | — | 39 | — | 100 | — | 43 |
| Platelet | — | 47 | — | 6 | — | 48 | — | 22 | — | 75 | — | 14 |
| Infection | ||||||||||||
| Febrile neutropenia | — | 11 | — | 1 | — | 6 | — | 0 | — | 0 | — | 0 |
| Bacteremia | — | 39 | — | 5 | — | 19 | — | 8 | — | 13 | — | 14 |
| Other infection | 13 | 1 | 4 | 0 | 5 | 0 | 12 | 0 | 13 | 0 | 0 | 0 |
| Lung infection | 6 | 1 | 0 | 0 | 2 | 0 | 12 | 0 | 0 | 0 | 0 | 0 |
| Soft tissue infection | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Others | 7 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 13 | 0 | 0 | 0 |
| . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nonhematologic | ||||||||||||
| Jaundice | 87 | 19 | 81 | 10 | 73 | 14 | 61 | 4 | 63 | 25 | 57 | 0 |
| ALT elevation | 79 | 17 | 67 | 8 | 65 | 5 | 58 | 0 | 38 | 0 | 57 | 0 |
| Azotemia | 12 | 0 | 5 | 0 | 18 | 3 | 29 | 4 | 0 | 0 | 14 | 0 |
| Lipase elevation | 24 | 13 | 15 | 7 | 17 | 9 | 0 | 0 | 33 | 0 | 0 | 0 |
| Anorexia | 2 | 0 | 4 | 0 | 8 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Nausea/vomiting | 55 | 5 | 24 | 1 | 40 | 5 | 42 | 0 | 25 | 0 | 29 | 0 |
| Dyspepsia | 36 | 1 | 9 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oral mucositis | 38 | 5 | 23 | 5 | 39 | 8 | 32 | 4 | 25 | 0 | 29 | 14 |
| Abdominal pain | 9 | 2 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 14 | 0 |
| Diarrhea | 30 | 5 | 10 | 0 | 23 | 3 | 4 | 0 | 0 | 0 | 0 | 0 |
| Fecal incontinence | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 0 |
| Constipation | 12 | 0 | 11 | 0 | 6 | 0 | 8 | 0 | 13 | 0 | 14 | 0 |
| Ileus | 8 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pancreatitis | 24 | 2 | 15 | 0 | 17 | 0 | 0 | 0 | 33 | 0 | 0 | 0 |
| Hemorrhage | 17 | 2 | 5 | 0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fever | 2 | 0 | 4 | 0 | 8 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Myalgia | 26 | 2 | 2 | 3 | 0 | 0 | 13 | 0 | 0 | 0 | 14 | 0 |
| Headache | 4 | 1 | 6 | 0 | 5 | 0 | 8 | 0 | 13 | 0 | 14 | 0 |
| Seizure | 0 | 0 | 0 | 0 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Peripheral neuropathy | 20 | 1 | 25 | 0 | 23 | 2 | 8 | 0 | 0 | 0 | 0 | 0 |
| Pruritus | 0 | 0 | 3 | 0 | 5 | 0 | 8 | 0 | 0 | 0 | 0 | 0 |
| Skin rash | 16 | 4 | 6 | 1 | 32 | 3 | 16 | 0 | 13 | 0 | 14 | 0 |
| Insomnia | 7 | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . | Total . | ≥G3 . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nonhematologic | ||||||||||||
| Jaundice | 87 | 19 | 81 | 10 | 73 | 14 | 61 | 4 | 63 | 25 | 57 | 0 |
| ALT elevation | 79 | 17 | 67 | 8 | 65 | 5 | 58 | 0 | 38 | 0 | 57 | 0 |
| Azotemia | 12 | 0 | 5 | 0 | 18 | 3 | 29 | 4 | 0 | 0 | 14 | 0 |
| Lipase elevation | 24 | 13 | 15 | 7 | 17 | 9 | 0 | 0 | 33 | 0 | 0 | 0 |
| Anorexia | 2 | 0 | 4 | 0 | 8 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Nausea/vomiting | 55 | 5 | 24 | 1 | 40 | 5 | 42 | 0 | 25 | 0 | 29 | 0 |
| Dyspepsia | 36 | 1 | 9 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oral mucositis | 38 | 5 | 23 | 5 | 39 | 8 | 32 | 4 | 25 | 0 | 29 | 14 |
| Abdominal pain | 9 | 2 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 14 | 0 |
| Diarrhea | 30 | 5 | 10 | 0 | 23 | 3 | 4 | 0 | 0 | 0 | 0 | 0 |
| Fecal incontinence | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 0 |
| Constipation | 12 | 0 | 11 | 0 | 6 | 0 | 8 | 0 | 13 | 0 | 14 | 0 |
| Ileus | 8 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pancreatitis | 24 | 2 | 15 | 0 | 17 | 0 | 0 | 0 | 33 | 0 | 0 | 0 |
| Hemorrhage | 17 | 2 | 5 | 0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fever | 2 | 0 | 4 | 0 | 8 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Myalgia | 26 | 2 | 2 | 3 | 0 | 0 | 13 | 0 | 0 | 0 | 14 | 0 |
| Headache | 4 | 1 | 6 | 0 | 5 | 0 | 8 | 0 | 13 | 0 | 14 | 0 |
| Seizure | 0 | 0 | 0 | 0 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
| Peripheral neuropathy | 20 | 1 | 25 | 0 | 23 | 2 | 8 | 0 | 0 | 0 | 0 | 0 |
| Pruritus | 0 | 0 | 3 | 0 | 5 | 0 | 8 | 0 | 0 | 0 | 0 | 0 |
| Skin rash | 16 | 4 | 6 | 1 | 32 | 3 | 16 | 0 | 13 | 0 | 14 | 0 |
| Insomnia | 7 | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
All values are percentiles. Dashes indicate that the number was omitted because specifying the exact number was not relevant in the table.
ANC, absolute neutrophil count; ALT, alanine aminotransferase; G4, grade 4; G3, grade 3.