Details of induction/consolidation chemotherapy
| Therapy . | Details . |
|---|---|
| Induction | Daunorubicin 90 mg/m2 per day; continuous IV infusion for 24 h, on days 1-3 |
| Vincristine 2 mg, IV push on days 1 and 8 | |
| Prednisolone 60 mg/m2 per day p.o., or 48 mg/m2 per day IV, on days 1-14 | |
| Nilotinib 400 mg p.o. twice daily (from day 8 to the start of conditioning for allo-HCT or until the end of 2 y of maintenance therapy) | |
| Consolidation A (cycle 1) | Daunorubicin 45 mg/m2 per day; continuous IV for 24 h on days 1 and 2 |
| Vincristine 2 mg IV, on days 1 and 8 | |
| Prednisolone 60 mg/m2 per day p.o., on days 1-14 | |
| Nilotinib 400 mg p.o. twice daily | |
| Consolidation B (cycles 2,4) | Cytarabine 2000 mg/m2 per day IV for 2 h on days 1-4 |
| Etoposide 150 mg/m2 per day IV for 3 h on days 1-4 | |
| Nilotinib 400 mg p.o. twice daily | |
| Consolidation C (cycles 3,5) | Methotrexate 220 mg/m2 IV bolus, then 60 mg/m2 per hour for 36 h on days 1-2 and 15-16 |
| Leucovorin, followed immediately by 50 mg/m2 IV every 6 h for 3 doses; then leucovorin p.o. until serum methotrexate <0.05 μmol/L | |
| Nilotinib 400 mg p.o. twice daily | |
| Maintenance | Nilotinib 400 mg p.o. twice daily for 2 y |
| CNS prophylaxis | Up to 10 doses of intrathecal methotrexate (15 mg) with hydrocortisone (50 mg) during or after induction therapy |
| Therapy . | Details . |
|---|---|
| Induction | Daunorubicin 90 mg/m2 per day; continuous IV infusion for 24 h, on days 1-3 |
| Vincristine 2 mg, IV push on days 1 and 8 | |
| Prednisolone 60 mg/m2 per day p.o., or 48 mg/m2 per day IV, on days 1-14 | |
| Nilotinib 400 mg p.o. twice daily (from day 8 to the start of conditioning for allo-HCT or until the end of 2 y of maintenance therapy) | |
| Consolidation A (cycle 1) | Daunorubicin 45 mg/m2 per day; continuous IV for 24 h on days 1 and 2 |
| Vincristine 2 mg IV, on days 1 and 8 | |
| Prednisolone 60 mg/m2 per day p.o., on days 1-14 | |
| Nilotinib 400 mg p.o. twice daily | |
| Consolidation B (cycles 2,4) | Cytarabine 2000 mg/m2 per day IV for 2 h on days 1-4 |
| Etoposide 150 mg/m2 per day IV for 3 h on days 1-4 | |
| Nilotinib 400 mg p.o. twice daily | |
| Consolidation C (cycles 3,5) | Methotrexate 220 mg/m2 IV bolus, then 60 mg/m2 per hour for 36 h on days 1-2 and 15-16 |
| Leucovorin, followed immediately by 50 mg/m2 IV every 6 h for 3 doses; then leucovorin p.o. until serum methotrexate <0.05 μmol/L | |
| Nilotinib 400 mg p.o. twice daily | |
| Maintenance | Nilotinib 400 mg p.o. twice daily for 2 y |
| CNS prophylaxis | Up to 10 doses of intrathecal methotrexate (15 mg) with hydrocortisone (50 mg) during or after induction therapy |
CNS, central nervous system; p.o., by mouth.