Demographic, clinical, and hematologic characteristics at diagnosis
| Characteristic . | Value . |
|---|---|
| Median (range) age (years) | 56 (29-78) |
| Sex (male/female) (n) | 37/16 |
| Race (n) | |
| White | 51 |
| Black | 1 |
| Asian | 1 |
| Hypertension (n) | 50 (94%) |
| GFR (n) | |
| CKD stage 1 | 0 |
| CKD stage 2/3 | 23 (43%) |
| CKD stage 4/5 (including RRT) | 30 (57%) |
| Mean eGFR (mL/min per year)* | 27 (0-79) |
| RRT before diagnosis (n) | |
| Dialysis | 9 (17%) |
| Transplant | 1 (2%) |
| Mean (range) urinary protein loss (g/24 hours) | 4.1 (0.1-15.5) |
| Nephrotic range proteinuria (n)† | 24/45 (53%) |
| Nephrotic syndrome (n)† | 10/45 (22%) |
| Microscopic hematuria (n)‡ | 45/50 (90%) |
| Extrarenal light chain deposits (n) | 5 (9.4%) |
| Heart | 2 (3.8%) |
| Liver | 2 (3.8%) |
| Lung | 1 (1.9%) |
| Nerve | 0 (0%) |
| Hematologic investigations | |
| Abnormal serum FLC concentration and ratio (n) | 53 (100%) |
| LC isotype κ | 43/53 (81%) |
| Λ | 10/53 (19%) |
| Median (range) pathogenic free light chain concentration (mg/L) | |
| κ | 724 (25.6-25 700) |
| Λ | 147 (29.8-742) |
| Median (range) FLC ratio ĸ:λ | |
| κ | 29.2 (2.9-150.8) |
| Λ | 0.17 (0.05-0.2) |
| Bence Jones proteinuria (n) | 20 (44.4%) |
| Monoclonal protein in serum detected by immunofixation (n) | 23 (43.4%) |
| No monoclonal protein detected by immunofixation (n) | 19 (35.8%) |
| Bone marrow findings | |
| ≥10% clonal plasma cells (n) | 6 (11.3%) |
| <10% clonal plasma cells (n) | 46 (86.8%) |
| Chronic lymphatic leukemia (n) | 1 (2%) |
| Characteristic . | Value . |
|---|---|
| Median (range) age (years) | 56 (29-78) |
| Sex (male/female) (n) | 37/16 |
| Race (n) | |
| White | 51 |
| Black | 1 |
| Asian | 1 |
| Hypertension (n) | 50 (94%) |
| GFR (n) | |
| CKD stage 1 | 0 |
| CKD stage 2/3 | 23 (43%) |
| CKD stage 4/5 (including RRT) | 30 (57%) |
| Mean eGFR (mL/min per year)* | 27 (0-79) |
| RRT before diagnosis (n) | |
| Dialysis | 9 (17%) |
| Transplant | 1 (2%) |
| Mean (range) urinary protein loss (g/24 hours) | 4.1 (0.1-15.5) |
| Nephrotic range proteinuria (n)† | 24/45 (53%) |
| Nephrotic syndrome (n)† | 10/45 (22%) |
| Microscopic hematuria (n)‡ | 45/50 (90%) |
| Extrarenal light chain deposits (n) | 5 (9.4%) |
| Heart | 2 (3.8%) |
| Liver | 2 (3.8%) |
| Lung | 1 (1.9%) |
| Nerve | 0 (0%) |
| Hematologic investigations | |
| Abnormal serum FLC concentration and ratio (n) | 53 (100%) |
| LC isotype κ | 43/53 (81%) |
| Λ | 10/53 (19%) |
| Median (range) pathogenic free light chain concentration (mg/L) | |
| κ | 724 (25.6-25 700) |
| Λ | 147 (29.8-742) |
| Median (range) FLC ratio ĸ:λ | |
| κ | 29.2 (2.9-150.8) |
| Λ | 0.17 (0.05-0.2) |
| Bence Jones proteinuria (n) | 20 (44.4%) |
| Monoclonal protein in serum detected by immunofixation (n) | 23 (43.4%) |
| No monoclonal protein detected by immunofixation (n) | 19 (35.8%) |
| Bone marrow findings | |
| ≥10% clonal plasma cells (n) | 6 (11.3%) |
| <10% clonal plasma cells (n) | 46 (86.8%) |
| Chronic lymphatic leukemia (n) | 1 (2%) |