Cumulative risk of HL in first-degree relatives of HL patients by family relationship and age at diagnosis compared with the population risk
| HL patients in the family and age at diagnosis (y) . | Cumulative risk % in relatives by relative’s age (y) . | Lifetime risk (0-79 y) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0-9 . | 0-19 . | 0-29 . | 0-39 . | 0-49 . | 0-59 . | 0-69 . | 0-79 . | 95% CI . | No. . | |
| Sibling | ||||||||||
| All | 0.0 | 0.1 | 0.4 | 0.5 | 0.6 | 0.7 | 0.9 | 0.9 | 0.6-1.1 | 86 |
| <30 | 0.0 | 0.1 | 0.4 | 0.6* | 0.7 | 0.7 | 1.1 | 1.1 | 0.3-1.8 | 49 |
| 30-59 | 0.0 | 0.1 | 0.3 | 0.4 | 0.6 | 0.8 | 0.8 | 0.8 | 0.5-1.2 | 36 |
| Parent/child | ||||||||||
| All | 0.0 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3-0.5 | 61 |
| <30 | 0.0 | 0.2 | 0.4 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.3-0.8 | 31 |
| 30-59 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.4 | 0.2-0.5 | 26 |
| ≥60 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.0-0.2 | 4 |
| Two or more first-degree relatives | ||||||||||
| All | 1.0 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 0.0-5.9 | 3 |
| <30 | 3.0† | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 0.0-17 | 3 |
| Same-sex twin | ||||||||||
| All | 0.0 | 0.0 | 4.0 | 4.0 | 5.5 | 5.5 | 13 | 13 | 0.0-26 | 6 |
| <30 | 0.0 | 0.0 | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 | 0.1-12 | 4 |
| Population risk | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3-0.3 | 28 732 |
| HL patients in the family and age at diagnosis (y) . | Cumulative risk % in relatives by relative’s age (y) . | Lifetime risk (0-79 y) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0-9 . | 0-19 . | 0-29 . | 0-39 . | 0-49 . | 0-59 . | 0-69 . | 0-79 . | 95% CI . | No. . | |
| Sibling | ||||||||||
| All | 0.0 | 0.1 | 0.4 | 0.5 | 0.6 | 0.7 | 0.9 | 0.9 | 0.6-1.1 | 86 |
| <30 | 0.0 | 0.1 | 0.4 | 0.6* | 0.7 | 0.7 | 1.1 | 1.1 | 0.3-1.8 | 49 |
| 30-59 | 0.0 | 0.1 | 0.3 | 0.4 | 0.6 | 0.8 | 0.8 | 0.8 | 0.5-1.2 | 36 |
| Parent/child | ||||||||||
| All | 0.0 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3-0.5 | 61 |
| <30 | 0.0 | 0.2 | 0.4 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.3-0.8 | 31 |
| 30-59 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.4 | 0.2-0.5 | 26 |
| ≥60 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.0-0.2 | 4 |
| Two or more first-degree relatives | ||||||||||
| All | 1.0 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 0.0-5.9 | 3 |
| <30 | 3.0† | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 8.4 | 0.0-17 | 3 |
| Same-sex twin | ||||||||||
| All | 0.0 | 0.0 | 4.0 | 4.0 | 5.5 | 5.5 | 13 | 13 | 0.0-26 | 6 |
| <30 | 0.0 | 0.0 | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 | 0.1-12 | 4 |
| Population risk | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3-0.3 | 28 732 |
Only those with at least 3 cases are presented.
Example 1: The 0-39 y cumulative risk of HL in a person with a family history of early-onset HL (before age 30 years) in his singleton sibling was 0.6%, whereas the correspondent risk in the general population was 0.1% (lifetime risk 1.1% vs 0.3% in the population).
Example 2: The 0-9 y cumulative risk of HL in a person with a family history of early-onset HL (before age 30 years) in 2 of his first-degree relatives was 3.0%, whereas the correspondent risk in the general population was 0.0% (lifetime risk 8.4% vs 0.3% in the population).