Table 1

Altered miRNA expression in CML CD34+ cells

Upregulated in CMLDownregulated in CML
miRNAlogFCAdjusted PmiRNAlogFCAdjusted P
hsa-miR-486-3p 2.3196694 6.99E-06 hsa-miR-146a −1.781099 4.84E-05 
hsa-miR-18b 2.1646587 4.84E-05 hsa-miR-551b −2.470109 .0003938 
hsa-miR-19a† 1.7367785 4.84E-05 hsa-miR-125b −1.260167 .0026857 
hsa-miR-486-5p 2.1636705 .0001093 hsa-miR-768-3p −1.216743 .009664 
hsa-miR-18a† 2.5785991 .0001093 hsa-miR-10a −1.686725 .009664 
hsa-miR-17† 2.0330101 .0001185 hsa-miR-21 −2.005972 .010417 
hsa-miR-20b 1.8770134 .0008293 hsa-miR-630 −3.466621 .0236791 
hsa-miR-93‡ 1.2873623 .0013853 hsa-miR-26a −0.739312 .0236791 
hsa-miR-20a† 1.6312808 .010417 hsa-miR-99a −0.881689 .0241247 
hsa-miR-106b‡ 0.869845 .0241247 hsa-miR-181c −0.907926 .0241247 
hsa-miR-17* 1.8963968 .0353565 hsa-miR-23a −1.049268 .0391509 
hsa-miR-363 1.0551691 .0393167 hsa-miR-151-5p −1.505794 .0531846 
hsa-miR-199b-5p 0.5604006 .0393167 hsa-miR-16 −0.564943 .0531846 
hsa-miR-361-5p 0.2939439 .0531846 hsa-miR-24 −0.80473 .0989177 
hsa-miR-324-5p 0.5038724 .0531846 hsa-miR-222 −0.893684 .1025662 
hsa-miR-324-3p 0.6832275 .0535795 hsa-miR-26b −0.751628 .1095676 
hsa-miR-92a 0.9787604 .056494 hsa-miR-768-5p −1.554897 .1121387 
hsa-miR-130b 0.8568465 .0734194 hsa-miR-23b −0.674667 .1334663 
hsa-miR-503 0.8823222 .0917508 hsa-miR-22 −2.852556 .1334663 
hsa-miR-19b 1.6196121 .1025662 hsa-miR-29c* −0.376277 .1587193 
hsa-miR-19b-1*† 1.0021163 .1025662 hsa-miR-10b −0.961031 .1768722 
hsa-miR-340* 0.7749786 .1095676 hsa-miR-922 −0.337589 .1768722 
hsa-miR-155 1.057247 .1334663 hsa-miR-596 −0.302939 .2051711 
hsa-miR-181a* 0.7631197 .1587193 hsa-miR-150 −3.752058 .2321378 
hsa-miR-513b 1.14356 .1941551    
hsa-miR-513c 0.6830905 .2016059    
hsa-miR-340 0.9628093 .2321378    
hsa-miR-92a-1*† 0.4735888 .2321378    
hsa-miR-25‡ 0.5208347 .2321378    
Upregulated in CMLDownregulated in CML
miRNAlogFCAdjusted PmiRNAlogFCAdjusted P
hsa-miR-486-3p 2.3196694 6.99E-06 hsa-miR-146a −1.781099 4.84E-05 
hsa-miR-18b 2.1646587 4.84E-05 hsa-miR-551b −2.470109 .0003938 
hsa-miR-19a† 1.7367785 4.84E-05 hsa-miR-125b −1.260167 .0026857 
hsa-miR-486-5p 2.1636705 .0001093 hsa-miR-768-3p −1.216743 .009664 
hsa-miR-18a† 2.5785991 .0001093 hsa-miR-10a −1.686725 .009664 
hsa-miR-17† 2.0330101 .0001185 hsa-miR-21 −2.005972 .010417 
hsa-miR-20b 1.8770134 .0008293 hsa-miR-630 −3.466621 .0236791 
hsa-miR-93‡ 1.2873623 .0013853 hsa-miR-26a −0.739312 .0236791 
hsa-miR-20a† 1.6312808 .010417 hsa-miR-99a −0.881689 .0241247 
hsa-miR-106b‡ 0.869845 .0241247 hsa-miR-181c −0.907926 .0241247 
hsa-miR-17* 1.8963968 .0353565 hsa-miR-23a −1.049268 .0391509 
hsa-miR-363 1.0551691 .0393167 hsa-miR-151-5p −1.505794 .0531846 
hsa-miR-199b-5p 0.5604006 .0393167 hsa-miR-16 −0.564943 .0531846 
hsa-miR-361-5p 0.2939439 .0531846 hsa-miR-24 −0.80473 .0989177 
hsa-miR-324-5p 0.5038724 .0531846 hsa-miR-222 −0.893684 .1025662 
hsa-miR-324-3p 0.6832275 .0535795 hsa-miR-26b −0.751628 .1095676 
hsa-miR-92a 0.9787604 .056494 hsa-miR-768-5p −1.554897 .1121387 
hsa-miR-130b 0.8568465 .0734194 hsa-miR-23b −0.674667 .1334663 
hsa-miR-503 0.8823222 .0917508 hsa-miR-22 −2.852556 .1334663 
hsa-miR-19b 1.6196121 .1025662 hsa-miR-29c* −0.376277 .1587193 
hsa-miR-19b-1*† 1.0021163 .1025662 hsa-miR-10b −0.961031 .1768722 
hsa-miR-340* 0.7749786 .1095676 hsa-miR-922 −0.337589 .1768722 
hsa-miR-155 1.057247 .1334663 hsa-miR-596 −0.302939 .2051711 
hsa-miR-181a* 0.7631197 .1587193 hsa-miR-150 −3.752058 .2321378 
hsa-miR-513b 1.14356 .1941551    
hsa-miR-513c 0.6830905 .2016059    
hsa-miR-340 0.9628093 .2321378    
hsa-miR-92a-1*† 0.4735888 .2321378    
hsa-miR-25‡ 0.5208347 .2321378    

logFC, log fold change (CML: normal).

†

miR-17-92 cluster.

‡

miR-106b-25 cluster.

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