Association of common variants with ADAMTS13 activity in the combined analysis of RS-I and RS-II
| SNP name . | Chromosome . | Position* . | Gene . | Effect/Other allele . | Frequency . | Imputation quality . | β . | P . |
|---|---|---|---|---|---|---|---|---|
| Adjusted for age, sex, and principal components 1-4 | ||||||||
| rs41314453 | 9 | 136 307 825 | ADAMTS13 | T/C | 1.88% | 0.84 | −21.7 | 1.2 × 10−63 |
| rs10456544 | 6 | 45 181 694 | SUPT3H | A/T | 7.11% | 0.69 | 4.2 | 1.1 × 10−8 |
| Additional adjustment for rs41314453 and rs10456544 | ||||||||
| rs3118667 | 9 | 136 291 063 | ADAMTS13 | C/T | 47.09% | 0.93 | 3.0 | 9.6 × 10−21 |
| Additional adjustment for rs3118667 | ||||||||
| rs139911703 | 9 | 136 081 887 | OBP2B | A/G | 1.10% | 0.52 | −11.6 | 3.6 × 10−8 |
| SNP name . | Chromosome . | Position* . | Gene . | Effect/Other allele . | Frequency . | Imputation quality . | β . | P . |
|---|---|---|---|---|---|---|---|---|
| Adjusted for age, sex, and principal components 1-4 | ||||||||
| rs41314453 | 9 | 136 307 825 | ADAMTS13 | T/C | 1.88% | 0.84 | −21.7 | 1.2 × 10−63 |
| rs10456544 | 6 | 45 181 694 | SUPT3H | A/T | 7.11% | 0.69 | 4.2 | 1.1 × 10−8 |
| Additional adjustment for rs41314453 and rs10456544 | ||||||||
| rs3118667 | 9 | 136 291 063 | ADAMTS13 | C/T | 47.09% | 0.93 | 3.0 | 9.6 × 10−21 |
| Additional adjustment for rs3118667 | ||||||||
| rs139911703 | 9 | 136 081 887 | OBP2B | A/G | 1.10% | 0.52 | −11.6 | 3.6 × 10−8 |
β, β coefficient, which should be interpreted as the change in ADAMTS13 activity (%) per 1 allele increase in the effect allele; frequency, frequency of the effect allele as a percentage; SNP, single nucleotide polymorphism.
The DNA position is coded according to the build 37.