Table 1 The HSC niche in acute and... | American Society of Hematology

Table 1

The HSC niche in acute and chronic myeloid neoplasms

Model	MSPC	Osteoblasts	Osteoclasts (TRAP+)	Adipocytes	Endothelial cells	SNS fibers	Hematopoietic cells	Reference
MLL-AF9 AML	↑ Nes-GFP⁺ cells ↑ PDGFRα⁺CD51⁺ cells ↑ Osteoprecursors (CD51⁺Sca1^–) ↓ NG2⁺ pericytes ↓ Niche factors	↓	↓	↓ Perilipin⁺ cells	↑ (CD31⁺Ter119^–CD45^–)	↓ Th⁺ fibers	NA	101
BCR-ABL blast crisis CML	↑CCL3 ↓ CFU-OB	↓	↓	NA	NA	NA	↑ CCL3	100
BCR-ABL CML	↑ CFU-F size ↑ Osteoprecursors (CD51⁺Sca1⁺) ↓ Niche factors	↑	—	NA	↓ (Lin^–CD45^–CD31⁺Sca-1⁺)	NA	↑ TPO ↑ CCL3	99
JAK2^V617F MPN	↓ Nes-GFP⁺ cells ↓ Niche factors ↑ IL-1R	NA	NA	NA	NA	↓ Th⁺ Fibers ↓ GFAP⁺ Schwann cells	↑ IL-1β	102

Model	MSPC	Osteoblasts	Osteoclasts (TRAP+)	Adipocytes	Endothelial cells	SNS fibers	Hematopoietic cells	Reference
MLL-AF9 AML	↑ Nes-GFP⁺ cells ↑ PDGFRα⁺CD51⁺ cells ↑ Osteoprecursors (CD51⁺Sca1^–) ↓ NG2⁺ pericytes ↓ Niche factors	↓	↓	↓ Perilipin⁺ cells	↑ (CD31⁺Ter119^–CD45^–)	↓ Th⁺ fibers	NA	101
BCR-ABL blast crisis CML	↑CCL3 ↓ CFU-OB	↓	↓	NA	NA	NA	↑ CCL3	100
BCR-ABL CML	↑ CFU-F size ↑ Osteoprecursors (CD51⁺Sca1⁺) ↓ Niche factors	↑	—	NA	↓ (Lin^–CD45^–CD31⁺Sca-1⁺)	NA	↑ TPO ↑ CCL3	99
JAK2^V617F MPN	↓ Nes-GFP⁺ cells ↓ Niche factors ↑ IL-1R	NA	NA	NA	NA	↓ Th⁺ Fibers ↓ GFAP⁺ Schwann cells	↑ IL-1β	102

CFU-OB; colony-forming unit-osteoblasts; GFAP, glial fibrillary acidic protein; IL-1R, interleukin 1 receptor; MPN, myeloproliferative neoplasm; NA, not available; SNS, sympathetic nervous system; TRAP, tartrate-resistant acid phosphatase; Th, tyrosine hydroxylase; TPO, thrombopoietin.

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