Table 2

JAK-STAT mutational status associated with patient demographic and clinical diagnostic and prognostic information

PLL_IDAge at DxSexATMATMinv(14)/TCL1+iso(8)IL2RGJAK1JAK3STAT5BJAK-STAT mutation statusPrevious treatment statusTime to relapse (days)Time to death (days)Survival
PLL_index1 47 M  T655fs X,14 Yes  S703I   Confirmed somatic Untreated 335 622 Dead 
PLL_index2 89 M Deletion  inv(14) Yes  V658F  Q706L Confirmed somatic Untreated  160 Dead 
PLL_index3 53 F  H2037R inv(14)  None: genome None: genome None: genome None: genome No mutation Unknown 1008 1077 Dead 
PLL_index4  M Unknown  inv(14) Yes None: genome None: genome None: genome None: genome No mutation Untreated  548 Dead 
PLL_1 71 M Deletion E73fs      T628S Confirmed somatic Untreated  1288 Dead 
PLL_2 69 F     None: exome None: exome None: exome None: exome No mutation Treated  2674 Dead 
PLL_3 81 F Deletion G2891RX add(14)    M511I  Confirmed somatic Untreated  103 Dead 
PLL_4 68 M   TCL1+   T901R   Confirmed somatic Untreated   Alive 
PLL_5 58 M  L2427R TCL1+     N642H Confirmed somatic Treated 791 1084 Dead 
PLL_6 61 F Unknown Unknown  Yes None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  192 Dead 
PLL_7 71 M  D2725V inv(14)   V658F   Confirmed somatic Untreated   Alive 
PLL_8 68 M Deletion V2727G TCL1+     Y665F Confirmed somatic Untreated  130 Dead 
PLL_9 68 M   del(14)    M511I  Confirmed somatic Treated  361 Dead 
PLL_10 60 M Deletion  inv(14)    M511I  Confirmed somatic Treated 924  Alive 
PLL_11 79 M Deletion D2719del inv(14)  None: exome None: exome None: exome None: exome No mutation Untreated   Alive 
PLL_12 80 M   TCL1+ Yes   M511I  Confirmed somatic Untreated 189 190 Dead 
PLL_13 62 M   inv(14)    M511I  Confirmed somatic Treated 335 754 Dead 
PLL_14 77 F Deletion I2899M inv(14)    M511I  Confirmed somatic Treated 2522 2871 Dead 
PLL_15 27 M        N642H Confirmed somatic Treated 2680  Alive 
PLL_16 36 F Deletion D2725E inv(14)    M511I  Confirmed somatic Untreated  561 Dead 
PLL_17 43 M   TCL1+     T628S Confirmed somatic Untreated   Alive 
PLL_18 71 M Deletion D2721NX 10,14 yes   K563_C565del  Confirmed somatic Untreated   Alive 
PLL_19 75 F Deletion S575fs     A573V  Confirmed somatic Treated 973 1122 Dead 
PLL_20   Deletion G2891D      N642H Confirmed somatic Unknown    
PLL_21 73 M Deletion A3006T  +8    N642H Confirmed somatic Treated 212 824 Dead 
PLL_22 74 F Unknown Unknown inv(14) +8 None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated   Alive 
PLL_23 61 F Deletion L2427P inv(14) iso(8)    Y665F Confirmed somatic Untreated 486  Alive 
PLL_24 60 M Deletion H2038D TCL1+ Unknown    T628S Confirmed somatic Untreated   Alive 
PLL_25 78 F Deletion L694R inv(14)  G628_S630del and K315E    Confirmed somatic Untreated   Alive 
PLL_26 72 M   TCL1+ Unknown None: exome None: exome None: exome None: exome No mutation Untreated 109 132 Dead 
PLL_27 45 M Deletion D2448N TCL1+ Unknown    N642H Confirmed somatic Untreated 111 342 Dead 
PLL_28 62 F Unknown Unknown TCL1+ +MYC None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  120 Dead 
PLL_29 63 M Deletion D2016G t(14q11) +8q24   M511I  Confirmed somatic Untreated  238 Dead 
PLL_30 63 M Unknown Unknown   None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated   Alive 
PLL_31 50 F  V2951I TCL1+ Unknown   Q507P  Confirmed somatic Untreated 443 560 Dead 
PLL_32 56 M Deletion R2453P TCL1+ +MYC   R657W  Mutation but normal tissue not available Treated 823 941 Dead 
PLL_33 52 M Deletion L319R TCL1+ Unknown    N642H Confirmed somatic Untreated 1643 2179 Dead 
PLL_34 58 M   TCL1+     N642H Confirmed somatic Untreated  609 Dead 
PLL_35 48 M Deletion D2725E and K224E inv(14) +MYC    N642H Confirmed somatic Untreated 276  Alive 
PLL_36 72 M  L2877F TCL1+ Unknown    N642H Confirmed somatic Untreated  129 Dead 
PLL_37 72 M   TCL1+ +MYC None: exome None: exome None: exome None: exome No mutation Untreated  612 Dead 
PLL_38 68 M  R3008C inv(14)    A573V  Confirmed somatic Untreated   Alive 
PLL_39 64 M Deletion S2859F TCL1+ Unknown  R629_D630del   Confirmed somatic Untreated   Alive 
PLL_40 71 M  Q1906X TCL1+ Unknown    N642H Confirmed somatic Untreated   Alive 
PLL_41 67 F Unknown Unknown inv(14)  None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  722 Dead 
PLL_42 67 M Unknown Unknown Unknown Unknown    N642H Confirmed somatic Untreated  92 Dead 
PLL_43 54 M   inv(14) Yes   M511I  Confirmed somatic Unknown 1461 1990 Dead 
PLL_44 73 M       M511I  Confirmed somatic Untreated  18 Dead 
PLL_45 58 M Deletion  inv(14) Yes None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  135 Dead 
PLL_46 57 M        R659C Confirmed somatic Untreated   Alive 
PLL_IDAge at DxSexATMATMinv(14)/TCL1+iso(8)IL2RGJAK1JAK3STAT5BJAK-STAT mutation statusPrevious treatment statusTime to relapse (days)Time to death (days)Survival
PLL_index1 47 M  T655fs X,14 Yes  S703I   Confirmed somatic Untreated 335 622 Dead 
PLL_index2 89 M Deletion  inv(14) Yes  V658F  Q706L Confirmed somatic Untreated  160 Dead 
PLL_index3 53 F  H2037R inv(14)  None: genome None: genome None: genome None: genome No mutation Unknown 1008 1077 Dead 
PLL_index4  M Unknown  inv(14) Yes None: genome None: genome None: genome None: genome No mutation Untreated  548 Dead 
PLL_1 71 M Deletion E73fs      T628S Confirmed somatic Untreated  1288 Dead 
PLL_2 69 F     None: exome None: exome None: exome None: exome No mutation Treated  2674 Dead 
PLL_3 81 F Deletion G2891RX add(14)    M511I  Confirmed somatic Untreated  103 Dead 
PLL_4 68 M   TCL1+   T901R   Confirmed somatic Untreated   Alive 
PLL_5 58 M  L2427R TCL1+     N642H Confirmed somatic Treated 791 1084 Dead 
PLL_6 61 F Unknown Unknown  Yes None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  192 Dead 
PLL_7 71 M  D2725V inv(14)   V658F   Confirmed somatic Untreated   Alive 
PLL_8 68 M Deletion V2727G TCL1+     Y665F Confirmed somatic Untreated  130 Dead 
PLL_9 68 M   del(14)    M511I  Confirmed somatic Treated  361 Dead 
PLL_10 60 M Deletion  inv(14)    M511I  Confirmed somatic Treated 924  Alive 
PLL_11 79 M Deletion D2719del inv(14)  None: exome None: exome None: exome None: exome No mutation Untreated   Alive 
PLL_12 80 M   TCL1+ Yes   M511I  Confirmed somatic Untreated 189 190 Dead 
PLL_13 62 M   inv(14)    M511I  Confirmed somatic Treated 335 754 Dead 
PLL_14 77 F Deletion I2899M inv(14)    M511I  Confirmed somatic Treated 2522 2871 Dead 
PLL_15 27 M        N642H Confirmed somatic Treated 2680  Alive 
PLL_16 36 F Deletion D2725E inv(14)    M511I  Confirmed somatic Untreated  561 Dead 
PLL_17 43 M   TCL1+     T628S Confirmed somatic Untreated   Alive 
PLL_18 71 M Deletion D2721NX 10,14 yes   K563_C565del  Confirmed somatic Untreated   Alive 
PLL_19 75 F Deletion S575fs     A573V  Confirmed somatic Treated 973 1122 Dead 
PLL_20   Deletion G2891D      N642H Confirmed somatic Unknown    
PLL_21 73 M Deletion A3006T  +8    N642H Confirmed somatic Treated 212 824 Dead 
PLL_22 74 F Unknown Unknown inv(14) +8 None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated   Alive 
PLL_23 61 F Deletion L2427P inv(14) iso(8)    Y665F Confirmed somatic Untreated 486  Alive 
PLL_24 60 M Deletion H2038D TCL1+ Unknown    T628S Confirmed somatic Untreated   Alive 
PLL_25 78 F Deletion L694R inv(14)  G628_S630del and K315E    Confirmed somatic Untreated   Alive 
PLL_26 72 M   TCL1+ Unknown None: exome None: exome None: exome None: exome No mutation Untreated 109 132 Dead 
PLL_27 45 M Deletion D2448N TCL1+ Unknown    N642H Confirmed somatic Untreated 111 342 Dead 
PLL_28 62 F Unknown Unknown TCL1+ +MYC None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  120 Dead 
PLL_29 63 M Deletion D2016G t(14q11) +8q24   M511I  Confirmed somatic Untreated  238 Dead 
PLL_30 63 M Unknown Unknown   None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated   Alive 
PLL_31 50 F  V2951I TCL1+ Unknown   Q507P  Confirmed somatic Untreated 443 560 Dead 
PLL_32 56 M Deletion R2453P TCL1+ +MYC   R657W  Mutation but normal tissue not available Treated 823 941 Dead 
PLL_33 52 M Deletion L319R TCL1+ Unknown    N642H Confirmed somatic Untreated 1643 2179 Dead 
PLL_34 58 M   TCL1+     N642H Confirmed somatic Untreated  609 Dead 
PLL_35 48 M Deletion D2725E and K224E inv(14) +MYC    N642H Confirmed somatic Untreated 276  Alive 
PLL_36 72 M  L2877F TCL1+ Unknown    N642H Confirmed somatic Untreated  129 Dead 
PLL_37 72 M   TCL1+ +MYC None: exome None: exome None: exome None: exome No mutation Untreated  612 Dead 
PLL_38 68 M  R3008C inv(14)    A573V  Confirmed somatic Untreated   Alive 
PLL_39 64 M Deletion S2859F TCL1+ Unknown  R629_D630del   Confirmed somatic Untreated   Alive 
PLL_40 71 M  Q1906X TCL1+ Unknown    N642H Confirmed somatic Untreated   Alive 
PLL_41 67 F Unknown Unknown inv(14)  None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  722 Dead 
PLL_42 67 M Unknown Unknown Unknown Unknown    N642H Confirmed somatic Untreated  92 Dead 
PLL_43 54 M   inv(14) Yes   M511I  Confirmed somatic Unknown 1461 1990 Dead 
PLL_44 73 M       M511I  Confirmed somatic Untreated  18 Dead 
PLL_45 58 M Deletion  inv(14) Yes None: Sanger None: Sanger None: Sanger None: Sanger No mutation Untreated  135 Dead 
PLL_46 57 M        R659C Confirmed somatic Untreated   Alive 

Index cases subjected to WGS are listed first. Deletions or point mutations in the 11q23 locus or ATM gene, respectively, are indicated. Karyotypic or immunohistochemical evidence of rearrangements involving the TCL1A/B or MTCP1 loci or TCL1 protein are indicated. Mutations identified in T-PLL cases are shown by gene. Cases for which no mutation was identified are indicated according to which method of mutation detection was employed. The patient’s treatment status at time of specimen collection is also indicated, as are the times from disease diagnosis to relapse or death and the patients’ survival status.

Dx, diagnosis; F, female; M, male.

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