HLA-DRB1 polymorphic amino acid positions associated with asparaginase hypersensitivity
| AA position (no leader)* . | Risk residue† . | P value (Padjusted)‡ . | OR‡ . | 95% CI . | Other possible amino acids¶ . | HLA-DRB1 alleles with risk residue . |
|---|---|---|---|---|---|---|
| 11 | G | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | D, G, L, P, S, V | *07:01 |
| 13 | Y | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | F, G, H, R, S, Y | *07:01 |
| 14 | K | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | E, K | *07:01 |
| 25 | Q | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | Q,R | *07:01 |
| 30 | L | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | C, G, H, L, R, Y | *07:01 |
| 57 | V | 1.19 × 10−3 (.023) | 1.53 | 1.18-1.98 | A, D, S | *07:01, *09:01, *12:01 |
| 60 | S | 1.19 × 10−3 (.023) | 1.53 | 1.18-1.98 | H, Y | *07:01, *09:01, *12:01 |
| 73 | G | 6.45 × 10−6 (<1.00 × 10−4) | 1.76 | 1.38-2.26 | A, G | *07:01,*03:01, *03:02 |
| 74 | Q | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | A, E, L, Q, R | *07:01 |
| 78 | V | 2.18 × 10−3 (.042) | 1.51 | 1.16-1.97 | V, Y | *07:01, *09:01 |
| AA position (no leader)* . | Risk residue† . | P value (Padjusted)‡ . | OR‡ . | 95% CI . | Other possible amino acids¶ . | HLA-DRB1 alleles with risk residue . |
|---|---|---|---|---|---|---|
| 11 | G | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | D, G, L, P, S, V | *07:01 |
| 13 | Y | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | F, G, H, R, S, Y | *07:01 |
| 14 | K | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | E, K | *07:01 |
| 25 | Q | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | Q,R | *07:01 |
| 30 | L | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | C, G, H, L, R, Y | *07:01 |
| 57 | V | 1.19 × 10−3 (.023) | 1.53 | 1.18-1.98 | A, D, S | *07:01, *09:01, *12:01 |
| 60 | S | 1.19 × 10−3 (.023) | 1.53 | 1.18-1.98 | H, Y | *07:01, *09:01, *12:01 |
| 73 | G | 6.45 × 10−6 (<1.00 × 10−4) | 1.76 | 1.38-2.26 | A, G | *07:01,*03:01, *03:02 |
| 74 | Q | 1.34 × 10−4 (.003) | 1.69 | 1.29-2.21 | A, E, L, Q, R | *07:01 |
| 78 | V | 2.18 × 10−3 (.042) | 1.51 | 1.16-1.97 | V, Y | *07:01, *09:01 |
AA position is the amino acid position of the HLA-DRB1 protein sequence without the leader signal sequence.
Risk residue is the amino acid associated with asparaginase hypersensitivity.
For the association between the risk residue and asparaginase hypersensitivity, Padjusted values were determined by permutation to account for multiple testing.
Other possible amino acids refer to other amino acids within that amino acid position observed in our patients (n = 1870).