Variable associated with adherence to oral 6MP for the entire cohort and within racial subgroups
| Variables . | Entire cohort, N = 298 . | Non-Hispanic whites, n = 159 . | Asian Americans, n = 71 . | African Americans, n = 68 . | ||||
|---|---|---|---|---|---|---|---|---|
| Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | |
| Intercept | 5.60† | — | 4.91† | — | 3.50† | — | 5.06† | — |
| Time on study | ||||||||
| Month 1 | — | 95.0 | — | 96.9 | — | 93.1 | — | 89.5 |
| Month 2 | −0.208‡ | 94.0 | −0.228§ | 96.1 | −0.53‡ | 91.7 | −0.068 | 88.7 |
| Month 3 | −0.427|| | 92.6 | −0.369|| | 95.6 | −1.01† | 89.9 | −0.196 | 87.3 |
| Month 4 | −0.520† | 92.0 | −0.567|| | 94.7 | −0.86|| | 89.0 | −0.347§ | 85.7 |
| Month 5 | −0.568† | 91.8 | −0.579|| | 94.7 | −1.0† | 88.6 | −0.373|| | 86.6 |
| P for linear trend | <.0001 | .002 | .0001 | .05 | ||||
| Annual household income | ||||||||
| ≥$50 000¶ | — | 95.3 | — | 96.7 | ||||
| <$50 000 | −0.86‡ | 89.7 | −1.68§ | 84.5 | ||||
| P | .005 | .04 | ||||||
| Gender | ||||||||
| Male¶ | ||||||||
| Female | ||||||||
| P | .15 | |||||||
| Race | ||||||||
| Non-Hispanic white¶ | — | 95.2 | ||||||
| Asian American | −0.80† | 90.0 | ||||||
| P | .01 | |||||||
| African American | −1.1† | 87.1 | ||||||
| P | <.0001 | |||||||
| Paternal education | ||||||||
| Postgraduate degree | — | 97.3 | ||||||
| Less than a postgraduate degree | −0.553‡ | 95.3 | ||||||
| P | .04 | |||||||
| Maternal education | ||||||||
| College degree/postgraduate/vocational training¶ | — | 94.6 | ||||||
| Less than a college degree | −1.46† | 78.9 | ||||||
| P | <.0001 | |||||||
| Household structure | ||||||||
| Single parent/single child¶ | — | 96.6 | — | 97.8 | — | 93.9 | ||
| Nuclear family | −0.94† | 92.3 | −0.69 | 95.7 | −0.77‡ | 86.5 | ||
| P | .04 | .04 | .07 | |||||
| Single parent/multiple children | −0.73† | 93.7 | −1.03§ | 94.0 | −0.69† | 85.9 | ||
| P | .01 | .05 | .18 | |||||
| Mother at home | ||||||||
| Stay-at-home mother¶ | — | 94.9 | — | 97.2 | ||||
| Working mother/absent mother | −0.62§ | 91.0 | −1.75|| | 85.6 | ||||
| P | .02 | .05 | ||||||
| Variables . | Entire cohort, N = 298 . | Non-Hispanic whites, n = 159 . | Asian Americans, n = 71 . | African Americans, n = 68 . | ||||
|---|---|---|---|---|---|---|---|---|
| Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | Parameter estimate* . | Estimated adherence, % . | |
| Intercept | 5.60† | — | 4.91† | — | 3.50† | — | 5.06† | — |
| Time on study | ||||||||
| Month 1 | — | 95.0 | — | 96.9 | — | 93.1 | — | 89.5 |
| Month 2 | −0.208‡ | 94.0 | −0.228§ | 96.1 | −0.53‡ | 91.7 | −0.068 | 88.7 |
| Month 3 | −0.427|| | 92.6 | −0.369|| | 95.6 | −1.01† | 89.9 | −0.196 | 87.3 |
| Month 4 | −0.520† | 92.0 | −0.567|| | 94.7 | −0.86|| | 89.0 | −0.347§ | 85.7 |
| Month 5 | −0.568† | 91.8 | −0.579|| | 94.7 | −1.0† | 88.6 | −0.373|| | 86.6 |
| P for linear trend | <.0001 | .002 | .0001 | .05 | ||||
| Annual household income | ||||||||
| ≥$50 000¶ | — | 95.3 | — | 96.7 | ||||
| <$50 000 | −0.86‡ | 89.7 | −1.68§ | 84.5 | ||||
| P | .005 | .04 | ||||||
| Gender | ||||||||
| Male¶ | ||||||||
| Female | ||||||||
| P | .15 | |||||||
| Race | ||||||||
| Non-Hispanic white¶ | — | 95.2 | ||||||
| Asian American | −0.80† | 90.0 | ||||||
| P | .01 | |||||||
| African American | −1.1† | 87.1 | ||||||
| P | <.0001 | |||||||
| Paternal education | ||||||||
| Postgraduate degree | — | 97.3 | ||||||
| Less than a postgraduate degree | −0.553‡ | 95.3 | ||||||
| P | .04 | |||||||
| Maternal education | ||||||||
| College degree/postgraduate/vocational training¶ | — | 94.6 | ||||||
| Less than a college degree | −1.46† | 78.9 | ||||||
| P | <.0001 | |||||||
| Household structure | ||||||||
| Single parent/single child¶ | — | 96.6 | — | 97.8 | — | 93.9 | ||
| Nuclear family | −0.94† | 92.3 | −0.69 | 95.7 | −0.77‡ | 86.5 | ||
| P | .04 | .04 | .07 | |||||
| Single parent/multiple children | −0.73† | 93.7 | −1.03§ | 94.0 | −0.69† | 85.9 | ||
| P | .01 | .05 | .18 | |||||
| Mother at home | ||||||||
| Stay-at-home mother¶ | — | 94.9 | — | 97.2 | ||||
| Working mother/absent mother | −0.62§ | 91.0 | −1.75|| | 85.6 | ||||
| P | .02 | .05 | ||||||
Analysis was adjusted for time from initiation of maintenance to study entry, NCI risk, blast chromosomal abnormalities and 6MP dose intensity. Age at study participation was not included in the model because of a lack of association with adherence. Test of homogeneity from month 1 through month 5: entire cohort, P < .0001; non-Hispanic white, P = .0006; Asian Americans, P = .0006; African Americans, P = .1. The individual P values for the parameter estimates for months 2 to 5 represent P values for change in adherence for each month, using month 1 as baseline.
More negative values of the parameter estimates indicate worse adherence rate when compared with the referent level which is indicated by ¶.
P < .001.
.01 ≤ P < .05.
.05 < P < .1.
.001 < P < .01.