Table 1 Characterization of B-cell... | American Society of Hematology

Table 1

Characterization of B-cell lymphomas in miR-217^KI mice

Mouse ID*	B-cell lymphoma†	Grade‡	Splenomegaly§	Phenotype¶
BPT048	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁺ sIgκ⁺ Fas⁺GL7⁺, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT100	FL		Yes	Mature B cells, Pax5⁺ BCL6⁻ and N/A
BPT105	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁻ sIgκ⁺, Pax5⁺ BCL6⁺
BPT106	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁻ sIgκ⁺, Pax5^low BCL6⁺
BPT109	PCT	Aggressive		Mature B cell, Pax5^- BCL6^- and N/A
BPT124	FL	Aggressive		Mature B cell, B220^low CD19⁺ sIgM^high sIgκ⁺, Pax5^low BCL6^-
BPT137	FL			Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5⁺ BCL6^-
BPT148	DLBCL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT224	DLBCL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ^low, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT226	FL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ^low, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT234	SBL			Mature B cell, B220⁺ CD19⁺ sIgM^high sIgκ⁺, Pax5⁺ BCL6^-
BPT263	FL		Yes	Mature B cell, B220^high CD19⁺ sIgM⁺ sIgκ⁺, Pax5⁺ BCL6⁺
BPT266	FL	Aggressive		Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5^low BCL6⁻

Mouse ID*	B-cell lymphoma†	Grade‡	Splenomegaly§	Phenotype¶
BPT048	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁺ sIgκ⁺ Fas⁺GL7⁺, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT100	FL		Yes	Mature B cells, Pax5⁺ BCL6⁻ and N/A
BPT105	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁻ sIgκ⁺, Pax5⁺ BCL6⁺
BPT106	FL			Mature B cell, B220⁺ CD19⁺ sIgM⁻ sIgκ⁺, Pax5^low BCL6⁺
BPT109	PCT	Aggressive		Mature B cell, Pax5^- BCL6^- and N/A
BPT124	FL	Aggressive		Mature B cell, B220^low CD19⁺ sIgM^high sIgκ⁺, Pax5^low BCL6^-
BPT137	FL			Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5⁺ BCL6^-
BPT148	DLBCL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT224	DLBCL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ^low, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT226	FL	Aggressive	Yes	Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ^low, Pax5^low BCL6⁺; numerous infiltrating T cells
BPT234	SBL			Mature B cell, B220⁺ CD19⁺ sIgM^high sIgκ⁺, Pax5⁺ BCL6^-
BPT263	FL		Yes	Mature B cell, B220^high CD19⁺ sIgM⁺ sIgκ⁺, Pax5⁺ BCL6⁺
BPT266	FL	Aggressive		Mature B cell, B220⁺ CD19⁺ sIgM^low sIgκ⁺, Pax5^low BCL6⁻

Mouse identification number.

SBL, small B-cell lymphoma.

Lymphoma classification grade.

Splenomegaly: spleens larger than 20 mm length.

Phenotype of tumoral cells determined by morphological features, flow cytometry, and immunohistochemica stainings. N/A, not analyzed.