Table 5

Cumulative rates (no. per 100 patient-years) of primary study outcomes in relation to age, sex, and type of index event in patients who did not resume anticoagulation

AgeSexType of index event
≤70 y>70 yP valueMalesFemalesP valueIdiopathicWRFP value
Patients with negative D-dimer, n (%) 327 (61.9) 201 (38.1)  277 (52.2) 251 (47.8)  377 (71.4) 151 (28.6)  
Primary outcomes, % (95% CI) 2.1 (0.9-4.4) 8.9 (5.4-13.8) .0008 4.7 (2.5-7.9) 4.8 (2.5-8.2) .886 6.1 (3.9-9) 1.3 (0.2-4.7) .036 
Patients with positive D-dimer who did not resume anticoagulation n (%) 77 (70.6) 32 (29.4)  70 (64.2) 39 (35.8)  83 (76.1) 26 (23.9)  
Primary outcomes, % (95% CI) 14.3 (7.4-24.1) 12.5 (3.5-29.0) .956 10.0 (4.1-19.5) 20.5 (9.3-36.5) .220 15.7 (8.6-25.3) 7.7 (1.0-25.1) .483 
AgeSexType of index event
≤70 y>70 yP valueMalesFemalesP valueIdiopathicWRFP value
Patients with negative D-dimer, n (%) 327 (61.9) 201 (38.1)  277 (52.2) 251 (47.8)  377 (71.4) 151 (28.6)  
Primary outcomes, % (95% CI) 2.1 (0.9-4.4) 8.9 (5.4-13.8) .0008 4.7 (2.5-7.9) 4.8 (2.5-8.2) .886 6.1 (3.9-9) 1.3 (0.2-4.7) .036 
Patients with positive D-dimer who did not resume anticoagulation n (%) 77 (70.6) 32 (29.4)  70 (64.2) 39 (35.8)  83 (76.1) 26 (23.9)  
Primary outcomes, % (95% CI) 14.3 (7.4-24.1) 12.5 (3.5-29.0) .956 10.0 (4.1-19.5) 20.5 (9.3-36.5) .220 15.7 (8.6-25.3) 7.7 (1.0-25.1) .483