Table 4 Clinical events occurred in the... | American Society of Hematology

Table 4

Clinical events occurred in the investigated patients

	Negative D-dimer, no anticoagulation (n = 528; 829 y)*	Positive D-dimer, anticoagulation refused (n = 109; 171 y)*	Positive D-dimer, anticoagulation resumed (n = 373; 601 y)*
Primary outcomes, n, % (95% CI)	25 (4.7%; 3.2-6.9)	15 (13.8%; 7.9-21.7)§	4 (1.1%; 0.3-2.7)
Incidence per 100 pt-y, % (95% CI)	3.0% (2.0-4.4)	8.8% (5.0-14.1)¶	0.7% (0.2-1.7)
Type of event (idiopathic), n
DVT	16 (14)	8 (6)	1
PE	5 (5)	3 (3)	2 (1)
DVT+PE	4 (3)	4 (2)	1
Other outcomes, n
Death†	1	0	5
Isolated distal DVT	9	2	0
SVT	19	2	2
Arterial vascular event	3	0	1
Major bleeding, n, % (95% CI)	0	0	14‡ (3.7%; 2.1-6.2)
Incidence per 100 pt-y, % (95% CI)			2.3% (1.3-3.9)

	Negative D-dimer, no anticoagulation (n = 528; 829 y)*	Positive D-dimer, anticoagulation refused (n = 109; 171 y)*	Positive D-dimer, anticoagulation resumed (n = 373; 601 y)*
Primary outcomes, n, % (95% CI)	25 (4.7%; 3.2-6.9)	15 (13.8%; 7.9-21.7)§	4 (1.1%; 0.3-2.7)
Incidence per 100 pt-y, % (95% CI)	3.0% (2.0-4.4)	8.8% (5.0-14.1)¶	0.7% (0.2-1.7)
Type of event (idiopathic), n
DVT	16 (14)	8 (6)	1
PE	5 (5)	3 (3)	2 (1)
DVT+PE	4 (3)	4 (2)	1
Other outcomes, n
Death†	1	0	5
Isolated distal DVT	9	2	0
SVT	19	2	2
Arterial vascular event	3	0	1
Major bleeding, n, % (95% CI)	0	0	14‡ (3.7%; 2.1-6.2)
Incidence per 100 pt-y, % (95% CI)			2.3% (1.3-3.9)

SVT, superficial vein thrombosis.

Total follow-up.

No death could be attributed to thrombotic event.

1 major bleeding was fatal.

P = .0008 patients with negative D-dimer.

P < .0009 vs patients with negative D-dimer.