Association of KIR and HLA class I ligands with incidence of childhood ALL
| . | Cases . | Controls . | OR (95% CI) . | P† . | ||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | |||
| ALL | ||||||
| C1/C1 | 98 | 30.6 | 592 | 39.1 | 0.69 (0.53-0.89) | .0051 |
| C1/C2 | 161 | 50.3 | 695 | 45.9 | 1.19 (0.94-1.52) | .1563 |
| C2/C2 | 61 | 19.1 | 228 | 15.0 | 1.33 (0.97-1.82) | .0764 |
| C1 alleles‡ | 357 | 55.8 | 1879 | 62.0 | 0.77 (0.65-0.92) | .0037 |
| C2 alleles | 283 | 44.2 | 1151 | 38.0 | 1.29 (1.09-1.54) | |
| B-ALL, German | ||||||
| C1/C1 | 57 | 27.9 | 420 | 41.2 | 0.54 (0.39-0.75) | .0004 |
| C1/C2 | 110 | 53.9 | 463 | 45.4 | 1.44 (1.07-1.95) | .0312 |
| C2/C2 | 37 | 18.1 | 137 | 13.4 | 1.44 (0.97-2.15) | .0987 |
| C1 alleles‡ | 224 | 54.9 | 1303 | 63.8 | 0.69 (0.56-0.85) | .0008 |
| C2 alleles | 184 | 45.1 | 737 | 36.2 | 1.45 (1.17-1.80) | |
| Bw4/Bw4 | 15 | 11.0 | 139 | 13.7 | 0.78 (0.44-1.37) | .4243 |
| Bw4/Bw6 | 68 | 50.0 | 481 | 47.6 | 1.10 (0.77-1.58) | .6478 |
| Bw6/Bw6 | 53 | 39.0 | 391 | 38.7 | 1.01 (0.70-1.46) | 1.0000 |
| KIR2DL1§ | ||||||
| 0 | 9 | 6.3 | 16 | 2.7 | 2.45 (1.06-5.67) | .0393 |
| 1 | 42 | 29.4 | 172 | 28.7 | 1.04 (0.69-1.55) | .9182 |
| 2 | 91 | 63.6 | 409 | 68.2 | 0.82 (0.56-1.20) | .3216 |
| 3 | 1 | 0.7 | 3 | 0.5 | 1.40 (0.15-13.5) | .5756 |
| *001/*002 | 85 | 41.1 | 357 | 35.7 | 1.25 (0.92-1.70) | .1542 |
| *003 | 89 | 43.0 | 452 | 45.2 | 0.91 (0.68-1.23) | .5912 |
| *004 | 32 | 15.5 | 186 | 18.6 | 0.80 (0.53-1.20) | .3212 |
| Other | 1 | 0.5 | 4 | 0.4 | 1.21 (0.13-10.86) | 1.0000 |
| KIR2DS1|| | ||||||
| 0 | 91 | 61.9 | 376 | 62.7 | 0.97 (0.67-1.40) | .9243 |
| 1 | 50 | 34.0 | 197 | 32.8 | 1.05 (0.72-1.54) | .8450 |
| 2 | 6 | 4.1 | 27 | 4.5 | 0.90 (0.37-2.23) | 1.0000 |
| . | Cases . | Controls . | OR (95% CI) . | P† . | ||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | |||
| ALL | ||||||
| C1/C1 | 98 | 30.6 | 592 | 39.1 | 0.69 (0.53-0.89) | .0051 |
| C1/C2 | 161 | 50.3 | 695 | 45.9 | 1.19 (0.94-1.52) | .1563 |
| C2/C2 | 61 | 19.1 | 228 | 15.0 | 1.33 (0.97-1.82) | .0764 |
| C1 alleles‡ | 357 | 55.8 | 1879 | 62.0 | 0.77 (0.65-0.92) | .0037 |
| C2 alleles | 283 | 44.2 | 1151 | 38.0 | 1.29 (1.09-1.54) | |
| B-ALL, German | ||||||
| C1/C1 | 57 | 27.9 | 420 | 41.2 | 0.54 (0.39-0.75) | .0004 |
| C1/C2 | 110 | 53.9 | 463 | 45.4 | 1.44 (1.07-1.95) | .0312 |
| C2/C2 | 37 | 18.1 | 137 | 13.4 | 1.44 (0.97-2.15) | .0987 |
| C1 alleles‡ | 224 | 54.9 | 1303 | 63.8 | 0.69 (0.56-0.85) | .0008 |
| C2 alleles | 184 | 45.1 | 737 | 36.2 | 1.45 (1.17-1.80) | |
| Bw4/Bw4 | 15 | 11.0 | 139 | 13.7 | 0.78 (0.44-1.37) | .4243 |
| Bw4/Bw6 | 68 | 50.0 | 481 | 47.6 | 1.10 (0.77-1.58) | .6478 |
| Bw6/Bw6 | 53 | 39.0 | 391 | 38.7 | 1.01 (0.70-1.46) | 1.0000 |
| KIR2DL1§ | ||||||
| 0 | 9 | 6.3 | 16 | 2.7 | 2.45 (1.06-5.67) | .0393 |
| 1 | 42 | 29.4 | 172 | 28.7 | 1.04 (0.69-1.55) | .9182 |
| 2 | 91 | 63.6 | 409 | 68.2 | 0.82 (0.56-1.20) | .3216 |
| 3 | 1 | 0.7 | 3 | 0.5 | 1.40 (0.15-13.5) | .5756 |
| *001/*002 | 85 | 41.1 | 357 | 35.7 | 1.25 (0.92-1.70) | .1542 |
| *003 | 89 | 43.0 | 452 | 45.2 | 0.91 (0.68-1.23) | .5912 |
| *004 | 32 | 15.5 | 186 | 18.6 | 0.80 (0.53-1.20) | .3212 |
| Other | 1 | 0.5 | 4 | 0.4 | 1.21 (0.13-10.86) | 1.0000 |
| KIR2DS1|| | ||||||
| 0 | 91 | 61.9 | 376 | 62.7 | 0.97 (0.67-1.40) | .9243 |
| 1 | 50 | 34.0 | 197 | 32.8 | 1.05 (0.72-1.54) | .8450 |
| 2 | 6 | 4.1 | 27 | 4.5 | 0.90 (0.37-2.23) | 1.0000 |
P values were calculated by Fisher’s exact test, ORs are denoted with 95% CI, and significant P values (after correction for multiple testing according to the Bonferroni method) are highlighted in bold.
Allele frequency = (x/n)/2 (where x is the number of alleles and n the number of individuals).
KIR2DL1 copy number (from 0-3 gene copies) and subtyping (indicated alleles) was performed for all cases and controls having C2. KIR2DL1*001 and *002 encode identical mature proteins and were not differentiated by our typing method.
KIR2DS1 copy number (from 0-2 gene copies) was performed for all cases and controls having C2.