Table 4

Association of ORM1 rs150611042 with ORM1 monocyte and macrophage expression

ORM1 rs150611042CTSGHS
NMonocyteMacrophageNMonocyte
CC* 664 6.80 (0.57) 6.19 (0.21) 1175 6.81 (0.38) 
CA* 79 6.45 (0.48) 6.12 (0.11) 196 6.62 (0.26) 
AA* 2 5.99 (0.09) 6.10 (0.09) 3 6.36 (0.04) 
R2, %  4.80 1.30  4.90 
P†  8.70 × 10−10 3.18 × 10−3  5.21 × 10−16 
ORM1 rs150611042CTSGHS
NMonocyteMacrophageNMonocyte
CC* 664 6.80 (0.57) 6.19 (0.21) 1175 6.81 (0.38) 
CA* 79 6.45 (0.48) 6.12 (0.11) 196 6.62 (0.26) 
AA* 2 5.99 (0.09) 6.10 (0.09) 3 6.36 (0.04) 
R2, %  4.80 1.30  4.90 
P†  8.70 × 10−10 3.18 × 10−3  5.21 × 10−16 

CTS, Cardiogenics Transcriptomics Study; GHS, Gutenberg Health Study.

*

Mean (SD).

†

Association testing was performed by regressing ORM1 expression on the imputed allele dosage of rs150611042 while adjusting for age, sex, and center (in CTS).

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