Results of meta-analysis of eligible studies examining prophylactic LMWH vs no LMWH in prevention of pregnancy complications in women with prior placenta-mediated pregnancy complications
| Outcome (LMWH = 288/control = 286) . | Proportion with outcome in the treatment group . | Proportion with outcome in the control group . | RR . | 95% CI . | P . | I2 (%) . | ||
|---|---|---|---|---|---|---|---|---|
| % . | n/N . | % . | n/N . | |||||
| Primary outcome | ||||||||
| Composite: any PE, abruption, SGA child (<10th percentile), or pregnancy loss >20 wk | 18.7 | 67/358 | 42.9 | 127/296 | 0.52 | 0.32-0.86 | .01 | 69 |
| Secondary outcomes | ||||||||
| Composite: severe PE (as defined by authors) or early-onset PE (<34 wk), abruption, SGA child (<5th percentile), or pregnancy loss >20 wk | 7.4 | 22/295 | 22.9 | 59/257 | 0.39 | 0.23-0.65 | .0004 | 20 |
| Any PE | 8.6 | 34/391 | 21.6 | 75/348 | 0.46 | 0.28-0.75 | .0019 | 33 |
| Severe or early PE | 1.7 | 6/352 | 13.4 | 42/313 | 0.16 | 0.07-0.36 | <.0001 | 0 |
| SGA <10th percentile | 10.1 | 39/386 | 29.4 | 96/327 | 0.42 | 0.29-0.59 | <.0001 | 0 |
| SGA <5th percentile | 5.0 | 15/302 | 9.9 | 30/302 | 0.52 | 0.28-0.94 | .03 | 0 |
| Abruption | 0.8 | 3/381 | 2.4 | 9/375 | 0.42 | 0.13-1.4 | .17 | 0 |
| Pregnancy loss <20 wk | 6.7 | 20/297 | 7.5 | 22/294 | 0.89 | 0.50-1.6 | .69 | 0 |
| Pregnancy loss >20 wk | 1.9 | 6/311 | 5.3 | 16/300 | 0.41 | 0.17-1.02 | .06 | 0 |
| Neonatal death | 0.6 | 2/315 | 2.6 | 8/308 | 0.31 | 0.07-1.3 | .10 | 0 |
| Delivery <37 wk | 32.1 | 95/296 | 47.7 | 124/260 | 0.77 | 0.62-0.96 | .02 | 0.4 |
| Delivery <34 wk | 7.9 | 28/356 | 19.3 | 62/322 | 0.45 | 0.30-0.69 | .0002 | 0 |
| Outcome (LMWH = 288/control = 286) . | Proportion with outcome in the treatment group . | Proportion with outcome in the control group . | RR . | 95% CI . | P . | I2 (%) . | ||
|---|---|---|---|---|---|---|---|---|
| % . | n/N . | % . | n/N . | |||||
| Primary outcome | ||||||||
| Composite: any PE, abruption, SGA child (<10th percentile), or pregnancy loss >20 wk | 18.7 | 67/358 | 42.9 | 127/296 | 0.52 | 0.32-0.86 | .01 | 69 |
| Secondary outcomes | ||||||||
| Composite: severe PE (as defined by authors) or early-onset PE (<34 wk), abruption, SGA child (<5th percentile), or pregnancy loss >20 wk | 7.4 | 22/295 | 22.9 | 59/257 | 0.39 | 0.23-0.65 | .0004 | 20 |
| Any PE | 8.6 | 34/391 | 21.6 | 75/348 | 0.46 | 0.28-0.75 | .0019 | 33 |
| Severe or early PE | 1.7 | 6/352 | 13.4 | 42/313 | 0.16 | 0.07-0.36 | <.0001 | 0 |
| SGA <10th percentile | 10.1 | 39/386 | 29.4 | 96/327 | 0.42 | 0.29-0.59 | <.0001 | 0 |
| SGA <5th percentile | 5.0 | 15/302 | 9.9 | 30/302 | 0.52 | 0.28-0.94 | .03 | 0 |
| Abruption | 0.8 | 3/381 | 2.4 | 9/375 | 0.42 | 0.13-1.4 | .17 | 0 |
| Pregnancy loss <20 wk | 6.7 | 20/297 | 7.5 | 22/294 | 0.89 | 0.50-1.6 | .69 | 0 |
| Pregnancy loss >20 wk | 1.9 | 6/311 | 5.3 | 16/300 | 0.41 | 0.17-1.02 | .06 | 0 |
| Neonatal death | 0.6 | 2/315 | 2.6 | 8/308 | 0.31 | 0.07-1.3 | .10 | 0 |
| Delivery <37 wk | 32.1 | 95/296 | 47.7 | 124/260 | 0.77 | 0.62-0.96 | .02 | 0.4 |
| Delivery <34 wk | 7.9 | 28/356 | 19.3 | 62/322 | 0.45 | 0.30-0.69 | .0002 | 0 |
n/N, number (n) with outcome/number (N) in treatment group.