Response to bortezomib and dexamethasone according to NRAS and KRAS mutation status
| . | Patients treated with bortezomib . | Patients treated with dexamethasone . | ||||
|---|---|---|---|---|---|---|
| R . | NR . | Total . | R . | NR . | Total . | |
| NRAS | ||||||
| Mutant | 1 | 14 | 15 | 3 | 3 | 6 |
| Wild-type | 31 | 28 | 59 | 8 | 17 | 25 |
| Total | 32 | 42 | P = .00116* | 11 | 20 | P = .64 |
| KRAS | ||||||
| Mutant | 9 | 8 | 17 | 3 | 6 | 9 |
| Wild-type | 23 | 34 | 57 | 8 | 14 | 22 |
| Total | 32 | 42 | P = .41 | 11 | 20 | P = 1.0 |
| . | Patients treated with bortezomib . | Patients treated with dexamethasone . | ||||
|---|---|---|---|---|---|---|
| R . | NR . | Total . | R . | NR . | Total . | |
| NRAS | ||||||
| Mutant | 1 | 14 | 15 | 3 | 3 | 6 |
| Wild-type | 31 | 28 | 59 | 8 | 17 | 25 |
| Total | 32 | 42 | P = .00116* | 11 | 20 | P = .64 |
| KRAS | ||||||
| Mutant | 9 | 8 | 17 | 3 | 6 | 9 |
| Wild-type | 23 | 34 | 57 | 8 | 14 | 22 |
| Total | 32 | 42 | P = .41 | 11 | 20 | P = 1.0 |
CR, complete response; MR, minimal response; NR, nonresponse (stable disease + PD); PD, progressive disease; PR, partial response.
R category equals complete, partial, or minimal response22; NR category equals stable or progressive disease. Similar results if R equals complete and partial response (see supplemental Table 13).
P = .016 after Bonferroni correction; P values calculated from 2-sided Fisher exact test.