Pathological features of mock- or HTLV-1–infected IBMI-huNOG mice
| Mouse ID* . | Wpi† . | PVL‡ . | CD3+CD4+ (%)§ . | CD4+CD25+ (%)§ . | Spleen weight (mg) . | Lymph node weight (mg)|| . | Observations . |
|---|---|---|---|---|---|---|---|
| 8807 | — | — | 16.7 | 2.6 | 45 | 1 | Mock infected |
| 8X10 | — | — | 20.2 | 3.4 | 51 | 3 | Mock infected |
| 8X20 | — | — | 36.5 | 4.4 | 40 | 2 | Mock infected |
| 8401 | 17 | 65.6 | 53.1 | 31.4 | 195 | 23 | |
| 8402 | 11 | 0.1 | 5.3 | 0.7 | 26 | 1 | |
| 8403 | 14 | 0.1 | 10.8 | 3.4 | 35 | 1 | |
| 8404 | 17 | 5.4 | 53.4 | 18.3 | 68 | 2 | |
| 8405 | 12 | 11.3 | 30.3 | 7.6 | 59 | 14 | |
| 8406 | 5 | 0.1 | 10.5 | 1.5 | 33 | 3 | |
| 8407 | 8 | 4.5 | 69.6 | 12.5 | 166 | 9 | |
| 8801 | 25 | 0.1 | 59.6 | 10.4 | 187 | 7 | |
| 8803 | 30 | 0.4 | 38.6 | 5.8 | 55 | 11 | |
| 8804 | 23 | 0.1 | 46.6 | 9.5 | 105 | 5 | |
| 8805 | 8 | 70.0 | 57.0 | 43.1 | 233 | 37 | Leukemia |
| 8808 | 8 | 26.5 | 52.5 | 20.6 | 101 | 40 | |
| 8810 | 4 | 42.2 | 55.4 | 21.3 | 40 | 22 | |
| 8X01 | 5 | 44.9 | 65.8 | 39.5 | 208 | 11 | |
| 8X04 | 8 | 121.9 | 62.2 | 43.5 | 165 | 7 | Leukemia |
| 8X05 | 23 | 127.7 | 81.4 | 73.9 | 226 | 8 | Leukemia, flower cells (10.6%),¶ tumor lesion |
| 8X06 | 9 | 31.6 | 50.5 | 25.5 | 155 | 5 | |
| 8X09 | 5 | 34.6 | 52.2 | 17.4 | 227 | 9 | |
| 8X12 | 4 | 47.9 | 58.5 | 16.2 | 188 | 11 | |
| 8X14 | 25 | 68.6 | 51.4 | 33.8 | 145 | 25 | Leukemia |
| 8X16 | 7 | 90.4 | 78.9 | 35.2 | 200 | 16 | Leukemia |
| 8X17# | 9 | 131.1 | 44.6 | 29.3 | 200 | 35 | Leukemia |
| 8X18 | 18 | 197.7 | 89.4 | 80.5 | 358 | 28 | Leukemia, flower cells (19.2%),¶ tumor lesion |
| 9Z01 | 10 | 53.6 | 75.8 | 47.9 | 220 | 12 | Leukemia |
| 9Z03 | 6 | 23.4 | 51.6 | 23.7 | 38 | 18 | |
| 9Z17 | 6 | 18.2 | 64.7 | 19.7 | 163 | 10 | |
| 9Z18 | 16 | 89.2 | 80.4 | 72.7 | 285 | 5 | Leukemia, flower cells (4.2%),¶ tumor lesion |
| 9Z19 | 6 | 35.0 | 65.0 | 45.9 | 207 | 20 | |
| X202 | 12 | 90.0 | 76.6 | 59.9 | 353 | 13 | Leukemia |
| X206 | 8 | 54.4 | 56.6 | 36.7 | 317 | 15 | |
| X207** | 11 | 100.0 | 62.2 | 55.7 | 358 | 6 | Leukemia |
| X208 | 4 | 29.9 | 74.7 | 18.4 | 188 | 15 | |
| X209 | 7 | 30.8 | 74.4 | 35.4 | 270 | 21 | |
| X212 | 9 | 74.9 | 56.8 | 37.4 | 270 | 5 | Leukemia |
| X214 | 10 | 44.3 | 48.0 | 33.3 | 170 | 6 | |
| X216 | 8 | 63.2 | 66.1 | 36.9 | 271 | 12 | Leukemia |
| X217 | 7 | 49.6 | 76.9 | 45.5 | 306 | 18 | Leukemia |
| Mouse ID* . | Wpi† . | PVL‡ . | CD3+CD4+ (%)§ . | CD4+CD25+ (%)§ . | Spleen weight (mg) . | Lymph node weight (mg)|| . | Observations . |
|---|---|---|---|---|---|---|---|
| 8807 | — | — | 16.7 | 2.6 | 45 | 1 | Mock infected |
| 8X10 | — | — | 20.2 | 3.4 | 51 | 3 | Mock infected |
| 8X20 | — | — | 36.5 | 4.4 | 40 | 2 | Mock infected |
| 8401 | 17 | 65.6 | 53.1 | 31.4 | 195 | 23 | |
| 8402 | 11 | 0.1 | 5.3 | 0.7 | 26 | 1 | |
| 8403 | 14 | 0.1 | 10.8 | 3.4 | 35 | 1 | |
| 8404 | 17 | 5.4 | 53.4 | 18.3 | 68 | 2 | |
| 8405 | 12 | 11.3 | 30.3 | 7.6 | 59 | 14 | |
| 8406 | 5 | 0.1 | 10.5 | 1.5 | 33 | 3 | |
| 8407 | 8 | 4.5 | 69.6 | 12.5 | 166 | 9 | |
| 8801 | 25 | 0.1 | 59.6 | 10.4 | 187 | 7 | |
| 8803 | 30 | 0.4 | 38.6 | 5.8 | 55 | 11 | |
| 8804 | 23 | 0.1 | 46.6 | 9.5 | 105 | 5 | |
| 8805 | 8 | 70.0 | 57.0 | 43.1 | 233 | 37 | Leukemia |
| 8808 | 8 | 26.5 | 52.5 | 20.6 | 101 | 40 | |
| 8810 | 4 | 42.2 | 55.4 | 21.3 | 40 | 22 | |
| 8X01 | 5 | 44.9 | 65.8 | 39.5 | 208 | 11 | |
| 8X04 | 8 | 121.9 | 62.2 | 43.5 | 165 | 7 | Leukemia |
| 8X05 | 23 | 127.7 | 81.4 | 73.9 | 226 | 8 | Leukemia, flower cells (10.6%),¶ tumor lesion |
| 8X06 | 9 | 31.6 | 50.5 | 25.5 | 155 | 5 | |
| 8X09 | 5 | 34.6 | 52.2 | 17.4 | 227 | 9 | |
| 8X12 | 4 | 47.9 | 58.5 | 16.2 | 188 | 11 | |
| 8X14 | 25 | 68.6 | 51.4 | 33.8 | 145 | 25 | Leukemia |
| 8X16 | 7 | 90.4 | 78.9 | 35.2 | 200 | 16 | Leukemia |
| 8X17# | 9 | 131.1 | 44.6 | 29.3 | 200 | 35 | Leukemia |
| 8X18 | 18 | 197.7 | 89.4 | 80.5 | 358 | 28 | Leukemia, flower cells (19.2%),¶ tumor lesion |
| 9Z01 | 10 | 53.6 | 75.8 | 47.9 | 220 | 12 | Leukemia |
| 9Z03 | 6 | 23.4 | 51.6 | 23.7 | 38 | 18 | |
| 9Z17 | 6 | 18.2 | 64.7 | 19.7 | 163 | 10 | |
| 9Z18 | 16 | 89.2 | 80.4 | 72.7 | 285 | 5 | Leukemia, flower cells (4.2%),¶ tumor lesion |
| 9Z19 | 6 | 35.0 | 65.0 | 45.9 | 207 | 20 | |
| X202 | 12 | 90.0 | 76.6 | 59.9 | 353 | 13 | Leukemia |
| X206 | 8 | 54.4 | 56.6 | 36.7 | 317 | 15 | |
| X207** | 11 | 100.0 | 62.2 | 55.7 | 358 | 6 | Leukemia |
| X208 | 4 | 29.9 | 74.7 | 18.4 | 188 | 15 | |
| X209 | 7 | 30.8 | 74.4 | 35.4 | 270 | 21 | |
| X212 | 9 | 74.9 | 56.8 | 37.4 | 270 | 5 | Leukemia |
| X214 | 10 | 44.3 | 48.0 | 33.3 | 170 | 6 | |
| X216 | 8 | 63.2 | 66.1 | 36.9 | 271 | 12 | Leukemia |
| X217 | 7 | 49.6 | 76.9 | 45.5 | 306 | 18 | Leukemia |
Leukemia, infected mice with atypical lymphocytes >90% of PBMCs; flower cells, atypical lymphocytes with >4 lobulated nuclei in a cell; tumor lesion, tumor formation of infiltrating infected T cells in the liver.
The 37 infected mice listed are identical to those in Figure 2E.
The wpi when indicated mice were sacrificed.
PVL is expressed as number of pX copies per 100 cells.
The population of indicated marker-positive cells in CD45+ splenocytes.
The weight value of one of the largest mesenteric lymph node in each mouse.
The percentage of flower cells in total lymphocytes in blood smear (presented in parentheses).
High proportion of CD25+ CD8 T cells in PBMCs.
High proportion of DP T cells in PBMCs.