IRC assessment of response
| Response category, n (%) . | BR (n = 213) . | R-CHOP/R-CVP (n = 206) . | CR-rate ratio* . | P (NI)† . | P (Sup)* . |
|---|---|---|---|---|---|
| CR | 67 (31) | 52 (25) | 1.26 | .0225 | .1269 |
| 95% CI | (25.3, 38.2) | (19.5, 31.7) | (0.93, 1.73) | ||
| Partial response | 139 (65) | 135 (66) | NA | NA | NA |
| Stable disease | 6 (3) | 18 (9) | NA | NA | NA |
| Progressive disease | 1 (<1) | 0 | NA | NA | NA |
| Unknown | 0 | 1 (<1) | NA | NA | NA |
| Overall response (CR + partial response) | 206 (97) | 187 (91) | NA | NA | NA |
| 95% CI | (93.3, 98.7) | (86.0, 94.4) | NA | NA | NA |
| Response category, n (%) . | BR (n = 213) . | R-CHOP/R-CVP (n = 206) . | CR-rate ratio* . | P (NI)† . | P (Sup)* . |
|---|---|---|---|---|---|
| CR | 67 (31) | 52 (25) | 1.26 | .0225 | .1269 |
| 95% CI | (25.3, 38.2) | (19.5, 31.7) | (0.93, 1.73) | ||
| Partial response | 139 (65) | 135 (66) | NA | NA | NA |
| Stable disease | 6 (3) | 18 (9) | NA | NA | NA |
| Progressive disease | 1 (<1) | 0 | NA | NA | NA |
| Unknown | 0 | 1 (<1) | NA | NA | NA |
| Overall response (CR + partial response) | 206 (97) | 187 (91) | NA | NA | NA |
| 95% CI | (93.3, 98.7) | (86.0, 94.4) | NA | NA | NA |
NA, not applicable.
CR-rate ratio and P value for a Sup test are calculated using the Cochran–Mantel–Haenszel test stratified by predetermined standard treatment and lymphoma type (mantle cell vs other types).
P value is calculated based on weighted z statistics for an NI test of CR-rate ratio (BR vs R-CHOP/R-CVP) of 0.88.