Roles of PAR1 and PAR2 in a mouse model of CVB3-induced myocarditis
| Mouse . | Results . | Conclusion . | Laboratory . | Reference . |
|---|---|---|---|---|
| PAR2ko mice | Increased IFN-β and CCL5 expression; decreased CVB3 genomes; decreased cardiac injury | PAR2 negatively regulates TLR3-dependent IFN-β expression. | Rauch | 42 |
| PAR1ko mice | Decreased IFN-β and CXCL10 expression; increased CVB3 genomes; increased cardiac injury | PAR1 positively regulates the TLR3-IFN-β pathway. | Mackman | 15 |
| Mouse . | Results . | Conclusion . | Laboratory . | Reference . |
|---|---|---|---|---|
| PAR2ko mice | Increased IFN-β and CCL5 expression; decreased CVB3 genomes; decreased cardiac injury | PAR2 negatively regulates TLR3-dependent IFN-β expression. | Rauch | 42 |
| PAR1ko mice | Decreased IFN-β and CXCL10 expression; increased CVB3 genomes; increased cardiac injury | PAR1 positively regulates the TLR3-IFN-β pathway. | Mackman | 15 |