Parameters obtained from thrombin generation on the PPP and PRP with FVNara
| . | Lag time (APC minus/plus, minutes [APCsr])* . | Time to peak (APC minus/plus, minutes [APCsr])* . | Peak thrombin (APC minus/plus, nM [APCsr])† . | ETP (APC minus/plus, nM × minutes [APCsr])† . |
|---|---|---|---|---|
| PPP | ||||
| Control | 2.50/2.62 (1.05) | 6.12/5.62 (0.92) | 242/70 (3.48) | 1648/446 (3.70) |
| FVNara | 12.3/12.5 (1.02) | 15.3/15.3 (1.00) | 176/144 (1.22) | 1711/1373 (1.25) |
| PRP | ||||
| Control | 3.01/6.55 (2.18) | 11.5/15.7 (1.36) | 191/71 (2.69) | 2860/968 (2.95) |
| FVNara | 12.8/18.2 (1.42) | 21.2/26.2 (1.23) | 169/103 (1.64) | 2811/1620 (1.74) |
| + FV (10 IU/dL) | 2.86/6.45 (2.25) | 11.5/16.2 (1.42) | 201/70 (2.87) | 2988/930 (3.21) |
| . | Lag time (APC minus/plus, minutes [APCsr])* . | Time to peak (APC minus/plus, minutes [APCsr])* . | Peak thrombin (APC minus/plus, nM [APCsr])† . | ETP (APC minus/plus, nM × minutes [APCsr])† . |
|---|---|---|---|---|
| PPP | ||||
| Control | 2.50/2.62 (1.05) | 6.12/5.62 (0.92) | 242/70 (3.48) | 1648/446 (3.70) |
| FVNara | 12.3/12.5 (1.02) | 15.3/15.3 (1.00) | 176/144 (1.22) | 1711/1373 (1.25) |
| PRP | ||||
| Control | 3.01/6.55 (2.18) | 11.5/15.7 (1.36) | 191/71 (2.69) | 2860/968 (2.95) |
| FVNara | 12.8/18.2 (1.42) | 21.2/26.2 (1.23) | 169/103 (1.64) | 2811/1620 (1.74) |
| + FV (10 IU/dL) | 2.86/6.45 (2.25) | 11.5/16.2 (1.42) | 201/70 (2.87) | 2988/930 (3.21) |