FV levels and APCR in plasmas of the patient and family members
| Case . | FV:C (IU/dL) . | FV:Ag (IU/dL) . | F5 mutation . | aPTT-based APCR assay . | ||
|---|---|---|---|---|---|---|
| aPTT, seconds . | APCsr (plus/minus APC) . | |||||
| Minus APC . | Plus APC . | |||||
| FVNara family members | ||||||
| Patient | 10.0 | 40.0 | W1920R homozygote | 79.7 | 131 | 1.64 |
| Father | 74.1 | 74.0 | W1920R heterozygote | 43.3 | 98.0 | 2.26 |
| Mother | 87.6 | 75.0 | W1920R heterozygote | 39.0 | 104 | 2.67 |
| Brother | 109 | 77.0 | WT | 32.2 | 98.4 | 3.06 |
| Sister-1 | 113 | 101 | WT | 32.6 | 107 | 3.28 |
| Sister-2 | 132 | 115 | WT | 32.2 | 99.8 | 3.10 |
| FVLeiden patient | ||||||
| Patient 1 | 56.5 | 96.0 | R506Q heterozygote | 35.2 | 57.2 | 1.63 |
| Patient 2 | 65.2 | 61.0 | R506Q heterozygote | 36.8 | 61.2 | 1.66 |
| FV-deficient patient | ||||||
| Patient 1 | 50.0 | 44.0 | 39.2 | 124 | 3.16 | |
| Patient 2 | 54.0 | 53.0 | 38.4 | 118 | 3.07 | |
| Patient 3 | 55.0 | 47.0 | 43.4 | 124 | 2.85 | |
| Healthy controls | ||||||
| Male (n = 17) | 32.6 ± 0.70 | 108.4 ± 4.50 | 3.32 ± 0.11 | |||
| Female (n = 15) | 33.5 ± 1.47 | 108.6 ± 3.64 | 3.24 ± 0.08 | |||
| Case . | FV:C (IU/dL) . | FV:Ag (IU/dL) . | F5 mutation . | aPTT-based APCR assay . | ||
|---|---|---|---|---|---|---|
| aPTT, seconds . | APCsr (plus/minus APC) . | |||||
| Minus APC . | Plus APC . | |||||
| FVNara family members | ||||||
| Patient | 10.0 | 40.0 | W1920R homozygote | 79.7 | 131 | 1.64 |
| Father | 74.1 | 74.0 | W1920R heterozygote | 43.3 | 98.0 | 2.26 |
| Mother | 87.6 | 75.0 | W1920R heterozygote | 39.0 | 104 | 2.67 |
| Brother | 109 | 77.0 | WT | 32.2 | 98.4 | 3.06 |
| Sister-1 | 113 | 101 | WT | 32.6 | 107 | 3.28 |
| Sister-2 | 132 | 115 | WT | 32.2 | 99.8 | 3.10 |
| FVLeiden patient | ||||||
| Patient 1 | 56.5 | 96.0 | R506Q heterozygote | 35.2 | 57.2 | 1.63 |
| Patient 2 | 65.2 | 61.0 | R506Q heterozygote | 36.8 | 61.2 | 1.66 |
| FV-deficient patient | ||||||
| Patient 1 | 50.0 | 44.0 | 39.2 | 124 | 3.16 | |
| Patient 2 | 54.0 | 53.0 | 38.4 | 118 | 3.07 | |
| Patient 3 | 55.0 | 47.0 | 43.4 | 124 | 2.85 | |
| Healthy controls | ||||||
| Male (n = 17) | 32.6 ± 0.70 | 108.4 ± 4.50 | 3.32 ± 0.11 | |||
| Female (n = 15) | 33.5 ± 1.47 | 108.6 ± 3.64 | 3.24 ± 0.08 | |||
All data were measured at least 3 times, and the average values are shown. For the levels of healthy controls, the average value ± standard deviation is shown.