Investigations for causes of sickle hepatopathy in SCD
| Investigation . |
|---|
| Clinical history and examination |
| Alcohol history |
| BMI |
| Drug history |
| Imaging |
| Liver USS including assessment of vessel patency and biliary system |
| Other imaging: CT abdomen, MRCP, ERCP |
| Laboratory |
| Viral serology: hepatitis B, hepatitis C, HIV, cytomegalovirus, Epstein-Barr virus, hepatitis A |
| Autoimmune screen: anti-nuclear antibody, anti–smooth muscle antibody, anti–liver/kidney antibody, anti–soluble liver antigen, anti-mitochondrial antibody |
| α-Feto-protein levels |
| Ceruloplasmin |
| α1-Antitrypsin |
| Liver biopsy |
| Usually not indicated unless genuine diagnostic dilemma |
| Iron status |
| Ferritin |
| MRI for liver iron concentration |
| Investigation . |
|---|
| Clinical history and examination |
| Alcohol history |
| BMI |
| Drug history |
| Imaging |
| Liver USS including assessment of vessel patency and biliary system |
| Other imaging: CT abdomen, MRCP, ERCP |
| Laboratory |
| Viral serology: hepatitis B, hepatitis C, HIV, cytomegalovirus, Epstein-Barr virus, hepatitis A |
| Autoimmune screen: anti-nuclear antibody, anti–smooth muscle antibody, anti–liver/kidney antibody, anti–soluble liver antigen, anti-mitochondrial antibody |
| α-Feto-protein levels |
| Ceruloplasmin |
| α1-Antitrypsin |
| Liver biopsy |
| Usually not indicated unless genuine diagnostic dilemma |
| Iron status |
| Ferritin |
| MRI for liver iron concentration |
ERCP, endoscopic retrograde cholangiopancreatography; MRCP, magnetic resonance cholangiopancreatography; USS, ultrasound scan.