Twenty-nine Rh antibodies in 25 patients associated with a significant change in hematologic parameters
| Antibody specificity . | Concurrent Antibodies . | ID . | Hemoglobin S (%) . | Hemoglobin (g/dL) . | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline . | At antibody detection . | Z-score* . | Baseline . | At antibody detection . | Z-score* . | |||
| Patients whose RBCs type positive for the corresponding antigen | ||||||||
| D (n = 12) | 292† | — | 81.7 | — | 6.5 | 4.2 | −5.7 | |
| E | 95 | 27.1 | 68.0 | 10.4 | 9.1 | 7.5 | −3.2 | |
| 41 | 25.9 | 38.2 | 5.9 | 9.4 | 8.9 | −2.4 | ||
| 78 | 28.8 | 45.1 | 5.4 | 10.2 | 9.7 | −0.5 | ||
| C | 138 | 19.3 | 61.6 | 4.3 | 10.4 | 8.2 | −4.0 | |
| C | 77 | 28.8 | 45.3 | 3.5 | 8.0 | 8.1 | 0.2 | |
| 110 | 27.6 | — | — | 10.6 | 7.9 | −2.7 | ||
| 50 | 44.3 | 58.8 | 1.6 | 8.5 | 6.4 | −2.8 | ||
| 99 | 29.6 | 45.7 | 2.5 | 8.9 | 8.2 | −1.0 | ||
| 34 | 18.2 | 23.3 | 2.2 | 8.8 | 8.7 | −0.2 | ||
| 145 | 26.0 | 32.7 | 2.1 | 9.5 | 9.5 | −0.1 | ||
| 100 | 24.8 | 40.6 | 2.0 | 8.9 | 7.5 | −1.8 | ||
| C (n = 3) | 95 | 25.3 | 31.2 | 1.0 | 9.3 | 5.0 | −6.9 | |
| D | 138 | 19.3 | 61.6 | 4.3 | 10.4 | 8.2 | −4.0 | |
| 85 | 28.9 | 44.0 | 2.7 | 9.8 | 8.8 | −2.3 | ||
| e (n = 5) | 65 | 29.0 | 43.6 | 4.9 | 8.7 | 8.2 | −0.7 | |
| 108 | 23.1 | 50.7 | 4.4 | 7.6 | 6.3 | −4.1 | ||
| C | 97† | — | 76.3 | — | 9.0 | 6.3 | −7.6 | |
| 100 | 26.4 | 40.6 | 2.1 | 8.6 | 8.1 | −2.7 | ||
| 86 | — | 89.5 | — | 7.7 | 6.9 | −2.1 | ||
| Patients whose RBCs type negative for the corresponding antigen and received antigen negative RBCs | ||||||||
| C (n = 4) | 28 | 25.1 | 45.8 | 8.0 | 9.4 | 8.7 | −1.3 | |
| D | 77 | 28.8 | 45.3 | 3.5 | 8.0 | 8.1 | 0.2 | |
| e | 97† | — | 76.3 | — | 9.0 | 6.3 | −7.6 | |
| 130 | 37.5 | 34.9 | −0.8 | 8.9 | 8.2 | −5.0 | ||
| E (n = 4) | D | 95 | 27.1 | 68.0 | 10.4 | 9.1 | 7.5 | −3.2 |
| 103 | 24.3 | 66.1 | 8.9 | 10.0 | 7.6 | −6.9 | ||
| 159 | 50 | — | — | 9.2 | 5.1 | −6.8 | ||
| Jkb | 31 | 43.1 | 91.5 | 2.0 | 7.9 | 6.8 | −1.1 | |
| Patients whose RBCs type negative for the corresponding antigen and received antigen positive RBCs | ||||||||
| E (n = 1) | 63‡ | 32.3 | 50.7 | 4.4 | 9.5 | 8.9 | −2.1 | |
| Antibody specificity . | Concurrent Antibodies . | ID . | Hemoglobin S (%) . | Hemoglobin (g/dL) . | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline . | At antibody detection . | Z-score* . | Baseline . | At antibody detection . | Z-score* . | |||
| Patients whose RBCs type positive for the corresponding antigen | ||||||||
| D (n = 12) | 292† | — | 81.7 | — | 6.5 | 4.2 | −5.7 | |
| E | 95 | 27.1 | 68.0 | 10.4 | 9.1 | 7.5 | −3.2 | |
| 41 | 25.9 | 38.2 | 5.9 | 9.4 | 8.9 | −2.4 | ||
| 78 | 28.8 | 45.1 | 5.4 | 10.2 | 9.7 | −0.5 | ||
| C | 138 | 19.3 | 61.6 | 4.3 | 10.4 | 8.2 | −4.0 | |
| C | 77 | 28.8 | 45.3 | 3.5 | 8.0 | 8.1 | 0.2 | |
| 110 | 27.6 | — | — | 10.6 | 7.9 | −2.7 | ||
| 50 | 44.3 | 58.8 | 1.6 | 8.5 | 6.4 | −2.8 | ||
| 99 | 29.6 | 45.7 | 2.5 | 8.9 | 8.2 | −1.0 | ||
| 34 | 18.2 | 23.3 | 2.2 | 8.8 | 8.7 | −0.2 | ||
| 145 | 26.0 | 32.7 | 2.1 | 9.5 | 9.5 | −0.1 | ||
| 100 | 24.8 | 40.6 | 2.0 | 8.9 | 7.5 | −1.8 | ||
| C (n = 3) | 95 | 25.3 | 31.2 | 1.0 | 9.3 | 5.0 | −6.9 | |
| D | 138 | 19.3 | 61.6 | 4.3 | 10.4 | 8.2 | −4.0 | |
| 85 | 28.9 | 44.0 | 2.7 | 9.8 | 8.8 | −2.3 | ||
| e (n = 5) | 65 | 29.0 | 43.6 | 4.9 | 8.7 | 8.2 | −0.7 | |
| 108 | 23.1 | 50.7 | 4.4 | 7.6 | 6.3 | −4.1 | ||
| C | 97† | — | 76.3 | — | 9.0 | 6.3 | −7.6 | |
| 100 | 26.4 | 40.6 | 2.1 | 8.6 | 8.1 | −2.7 | ||
| 86 | — | 89.5 | — | 7.7 | 6.9 | −2.1 | ||
| Patients whose RBCs type negative for the corresponding antigen and received antigen negative RBCs | ||||||||
| C (n = 4) | 28 | 25.1 | 45.8 | 8.0 | 9.4 | 8.7 | −1.3 | |
| D | 77 | 28.8 | 45.3 | 3.5 | 8.0 | 8.1 | 0.2 | |
| e | 97† | — | 76.3 | — | 9.0 | 6.3 | −7.6 | |
| 130 | 37.5 | 34.9 | −0.8 | 8.9 | 8.2 | −5.0 | ||
| E (n = 4) | D | 95 | 27.1 | 68.0 | 10.4 | 9.1 | 7.5 | −3.2 |
| 103 | 24.3 | 66.1 | 8.9 | 10.0 | 7.6 | −6.9 | ||
| 159 | 50 | — | — | 9.2 | 5.1 | −6.8 | ||
| Jkb | 31 | 43.1 | 91.5 | 2.0 | 7.9 | 6.8 | −1.1 | |
| Patients whose RBCs type negative for the corresponding antigen and received antigen positive RBCs | ||||||||
| E (n = 1) | 63‡ | 32.3 | 50.7 | 4.4 | 9.5 | 8.9 | −2.1 | |
For each antibody, the percent hemoglobin S and hemoglobin level at the time of first detection is indicated and compared with the patient’s individual baseline value (see Methods). For antibody specificity, the second entry indicates additional antibodies detected concurrently. —, data not available.
Z-score >2.0 for hemoglobin S level or <−2.0 for hemoglobin level correlates with P < .05, indicated in bold. ID in bold indicates patients with >1 Rh antibody detected concurrently.
Episodically transfused.
E− transfused with E+ RBCs for management of anti-e.