Table 2

Indications for allogeneic HSCT by subgroup

SubgroupIndications for allogeneic HSCTType of donor
MFDMUD
1 PPR and: WBC count ≥100 000/mm3 or T-cell ALL or pro–B-cell ALL or MRD ≥10−2 at TP1* Yes No 
2 MRD-HR 10−3 at TP2* or t(4;11) and PGR Yes No 
3 MRD-HR ≥10−2 at TP2* or no remission at +33 or t(4;11) and PPR Yes Yes 
SubgroupIndications for allogeneic HSCTType of donor
MFDMUD
1 PPR and: WBC count ≥100 000/mm3 or T-cell ALL or pro–B-cell ALL or MRD ≥10−2 at TP1* Yes No 
2 MRD-HR 10−3 at TP2* or t(4;11) and PGR Yes No 
3 MRD-HR ≥10−2 at TP2* or no remission at +33 or t(4;11) and PPR Yes Yes 

PGR, prednisone good response.

*

MRD level 10−3 indicates the interval of values between ≥5 × 10−4 and <5 × 10−3; MRD level ≥10−2 includes all values ≥5 × 10−3.

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