Characteristics of 4468 AA participants by cohort
| Study . | ARIC . | CARDIA . | MESA . | WHI . | Total* . | P value for differences between cohorts . |
|---|---|---|---|---|---|---|
| Sample size | 2354 | 353 | 1607 | 154 | 4468 | — |
| Age, y (SD) | 53.3 (5.8) | 24.9 (4.4) | 62.2 (10.1) | 65.2 (6.5) | 54.8 (12.4) | <.0001 |
| Female (%) | 63 | 61 | 54 | 100 | 61 | <.0001 |
| BMI (SD) | 29.7 (6.1) | 25.4 (5.7) | 29.9 (5.5) | 31.3 (5.1) | 29.3 (6.2) | <.0001 |
| Current smoker | 28.9% | 33.9% | 24.7% | 29.4% | 27.8% | <.0001 |
| VWF antigen, IU/dL (SD) | 135 (58) | 102 (42) | 154 (62) | 123 (66) | 132 (58) | <.0001 |
| FVIII activity, IU/dL (SD) | 148 (48) | 102 (38) | 115 (47) | 123 (63) | 128 (15) | <.0001 |
| FVIII/VWF ratio | 1.18 (0.33) | 1.12 (0.53) | 1.20 (0.40) | 1.15 (0.62) | 1.18 (0.37) | .02 |
| Ristocetin cofactor activity | NA | 92 (40) | NA | NA | 92 (40) | — |
| Study . | ARIC . | CARDIA . | MESA . | WHI . | Total* . | P value for differences between cohorts . |
|---|---|---|---|---|---|---|
| Sample size | 2354 | 353 | 1607 | 154 | 4468 | — |
| Age, y (SD) | 53.3 (5.8) | 24.9 (4.4) | 62.2 (10.1) | 65.2 (6.5) | 54.8 (12.4) | <.0001 |
| Female (%) | 63 | 61 | 54 | 100 | 61 | <.0001 |
| BMI (SD) | 29.7 (6.1) | 25.4 (5.7) | 29.9 (5.5) | 31.3 (5.1) | 29.3 (6.2) | <.0001 |
| Current smoker | 28.9% | 33.9% | 24.7% | 29.4% | 27.8% | <.0001 |
| VWF antigen, IU/dL (SD) | 135 (58) | 102 (42) | 154 (62) | 123 (66) | 132 (58) | <.0001 |
| FVIII activity, IU/dL (SD) | 148 (48) | 102 (38) | 115 (47) | 123 (63) | 128 (15) | <.0001 |
| FVIII/VWF ratio | 1.18 (0.33) | 1.12 (0.53) | 1.20 (0.40) | 1.15 (0.62) | 1.18 (0.37) | .02 |
| Ristocetin cofactor activity | NA | 92 (40) | NA | NA | 92 (40) | — |
Mean (SD) values are shown for age, body mass index, VWF antigen, FVIII activity, FVIII/VWF ratio, and ristocetin cofactor activity.
BMI, body mass index; NA, not available; SD, standard deviation.
Of the total of 4468 AA participants, VWF levels were measured in 2989 and FVIII levels were measured in 4430. Both measurements were available in 2951 participants. Ristocetin cofactor activity was measured in 165 CARDIA participants.