Table 1 Selected studies in stage I to... | American Society of Hematology

Table 1

Selected studies in stage I to II NLPHL

	n	Median follow-up, y	Treatment	Outcome (%)			OS (%)	Comments
Chen et al, 2010³⁴	113	11.3	RT 82%	10 y	PFS	Limited RT, 64	Limited RT, 100	Extent of RT did not affect PFS or OS. CMT did not affect PFS but was associated with worse OS
			CMT 12%			Regional RT, 84	Regional RT, 95
			CHT 6%			Extended RT, 81	Extended RT, 95
			CHT 6%			CHT only, 14	CHT only, 83
Nogova et al, 2005³²	131	3.6	RT 69%	2 y	FFTF	EFRT, 100	100	Included only stage IA without risk factors
			CMT 31%			IFRT, 92
			CMT 31%			CMT, 97
Feugier et al, 2004²³	42	NA	CMT	15 y	FFP	80	86	Brief chemo and EFRT
Wilder et al, 2002⁴⁴	48	9.3	RT 77%	10 y	RFS	RT, 77	90	Variable radiation field size
Wilder et al, 2002⁴⁴	48	9.3	CMT 23%	10 y	RFS	CMT, 68	100	Variable radiation field size
Wirth et al, 2005³⁵	202	15	RT	15 y	FFP	82	83	No effect of radiation field size
Savage et al, 2011⁴⁵	51	5.7	CHT^+/− RT	10 y	PFS	93	93	Patients treated with CT only had negative interim PET scans
Savage et al, 2011⁴⁵	35	18.6	RT only	10 y	PFS	77.5	85
Shankar et al, 2012⁴⁶	55	3.3	CHT	3.3 y	FFTF	75.4	100	All children, <18 y
Mauz-Korholtz et al, 2007⁴²	58	3.6	Excision	4.2 y	PFS	57	100	All children, <18 y

	n	Median follow-up, y	Treatment	Outcome (%)			OS (%)	Comments
Chen et al, 2010³⁴	113	11.3	RT 82%	10 y	PFS	Limited RT, 64	Limited RT, 100	Extent of RT did not affect PFS or OS. CMT did not affect PFS but was associated with worse OS
			CMT 12%			Regional RT, 84	Regional RT, 95
			CHT 6%			Extended RT, 81	Extended RT, 95
			CHT 6%			CHT only, 14	CHT only, 83
Nogova et al, 2005³²	131	3.6	RT 69%	2 y	FFTF	EFRT, 100	100	Included only stage IA without risk factors
			CMT 31%			IFRT, 92
			CMT 31%			CMT, 97
Feugier et al, 2004²³	42	NA	CMT	15 y	FFP	80	86	Brief chemo and EFRT
Wilder et al, 2002⁴⁴	48	9.3	RT 77%	10 y	RFS	RT, 77	90	Variable radiation field size
Wilder et al, 2002⁴⁴	48	9.3	CMT 23%	10 y	RFS	CMT, 68	100	Variable radiation field size
Wirth et al, 2005³⁵	202	15	RT	15 y	FFP	82	83	No effect of radiation field size
Savage et al, 2011⁴⁵	51	5.7	CHT^+/− RT	10 y	PFS	93	93	Patients treated with CT only had negative interim PET scans
Savage et al, 2011⁴⁵	35	18.6	RT only	10 y	PFS	77.5	85
Shankar et al, 2012⁴⁶	55	3.3	CHT	3.3 y	FFTF	75.4	100	All children, <18 y
Mauz-Korholtz et al, 2007⁴²	58	3.6	Excision	4.2 y	PFS	57	100	All children, <18 y

CHT, chemotherapy; NA, not reported/not available.